Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
SPARC (human)

Overview
SPARC Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. Belongs to the SPARC family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 5q31.3-q32
Cellular Component: basement membrane; cell surface; cytoplasm; extracellular region; extracellular space; mitochondrion; nuclear matrix; plasma membrane; platelet alpha granule membrane
Molecular Function: calcium ion binding; collagen binding; extracellular matrix binding; protein binding
Biological Process: blood coagulation; extracellular matrix organization and biogenesis; heart development; inner ear development; lung development; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; ossification; platelet activation; platelet degranulation; receptor-mediated endocytosis; regulation of cell morphogenesis; response to cadmium ion; response to calcium ion; response to cAMP; response to cytokine stimulus; response to ethanol; response to glucocorticoid stimulus; response to gravity; response to L-ascorbic acid; response to lead ion; response to lipopolysaccharide; response to peptide hormone stimulus; signal transduction
Disease: Osteogenesis Imperfecta, Type Xvii
Reference #:  P09486 (UniProtKB)
Alt. Names/Synonyms: Basement-membrane protein 40; BM-40; cysteine-rich protein; ON; Osteonectin; Secreted protein acidic and rich in cysteine; secreted protein, acidic, cysteine-rich (osteonectin); SPARC; SPRC
Gene Symbols: SPARC
Molecular weight: 34,632 Da
Basal Isoelectric point: 4.73  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SPARC

Protein Structure Not Found.


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y145‑p GHKLHLDyIGPCKYI
  mouse

 
Y144 GHKLHLDYIGPCKYI
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.