Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. Belongs to the SPARC family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 5q31.3-q32
Molecular Function: calcium ion binding; collagen binding; extracellular matrix binding; protein binding
Biological Process: blood coagulation; extracellular matrix organization and biogenesis; heart development; inner ear development; lung development; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; ossification; platelet activation; platelet degranulation; receptor-mediated endocytosis; regulation of cell morphogenesis; response to cadmium ion; response to calcium ion; response to cAMP; response to cytokine stimulus; response to ethanol; response to glucocorticoid stimulus; response to gravity; response to L-ascorbic acid; response to lead ion; response to lipopolysaccharide; response to peptide hormone stimulus; signal transduction
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.