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Protein Page:
SHH (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SHH Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Interacts with HHATL/GUP1 which negatively regulates HHAT-mediated palmitoylation of the SHH N-terminus. N-product is active as a multimer. Expressed in fetal intestine, liver, lung, and kidney. Not expressed in adult tissues. Belongs to the hedgehog family. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Cell cycle regulation; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 7q36
Cellular Component: cell surface; cytosol; endoplasmic reticulum lumen; extracellular region; extracellular space; lipid raft; plasma membrane; proteinaceous extracellular matrix
Molecular Function: calcium ion binding; glycoprotein binding; glycosaminoglycan binding; laminin-1 binding; morphogen activity; patched binding; peptidase activity; protein binding; zinc ion binding
Biological Process: activation of hh target transcription factor; androgen metabolic process; axon guidance; Bergmann glial cell differentiation; blood coagulation; branching morphogenesis of a tube; camera-type eye development; CD4-positive or CD8-positive, alpha-beta T cell lineage commitment; cell development; cell fate specification; cell-cell signaling; central nervous system development; dorsal/ventral pattern formation; dorsoventral neural tube patterning; ectoderm development; embryonic development; embryonic digit morphogenesis; embryonic foregut morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic limb morphogenesis; embryonic pattern specification; embryonic skeletal development; endocytosis; establishment of cell polarity; forebrain development; formation of anatomical boundary; granule cell precursor proliferation; hair follicle morphogenesis; heart development; heart looping; hindbrain development; hindgut morphogenesis; inner ear development; intein-mediated protein splicing; intermediate filament organization; limb bud formation; lung development; lymphoid progenitor cell differentiation; male genitalia development; metanephros development; midbrain development; myoblast differentiation; myotube differentiation; negative regulation of alpha-beta T cell differentiation; negative regulation of apoptosis; negative regulation of cell differentiation; negative regulation of cell migration; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of T cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative thymic T cell selection; neural crest cell migration; neuroblast proliferation; neuron fate commitment; odontogenesis of dentine-containing teeth; oligodendrocyte development; organ formation; osteoblast development; palate development; pancreas development; pattern specification process; patterning of blood vessels; polarity specification of anterior/posterior axis; positive regulation of alpha-beta T cell differentiation; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of immature T cell proliferation in the thymus; positive regulation of neuroblast proliferation; positive regulation of oligodendrocyte differentiation; positive regulation of protein import into nucleus; positive regulation of skeletal muscle cell proliferation; positive regulation of skeletal muscle development; positive regulation of smoothened signaling pathway; positive regulation of striated muscle cell differentiation; positive regulation of T cell differentiation in the thymus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of Wnt receptor signaling pathway; positive thymic T cell selection; prostate gland development; regulation of cell proliferation; regulation of odontogenesis; regulation of proteolysis; smoothened signaling pathway; smoothened signaling pathway in regulation of granule cell precursor cell proliferation; spinal cord motor neuron differentiation; stem cell development; striated muscle development; T cell differentiation in the thymus; telencephalon regionalization; thalamus development; thymus development; thyroid gland development; ureteric bud branching; vasculogenesis; ventral midline development; Wnt receptor signaling pathway through beta-catenin
Disease: Holoprosencephaly 3; Microphthalmia, Isolated, With Coloboma 5; Schizencephaly; Solitary Median Maxillary Central Incisor
Reference #:  Q15465 (UniProtKB)
Alt. Names/Synonyms: HHG-1; HHG1; HLP3; HPE3; MCOPCB5; SHH; SMMCI; sonic hedgehog homolog (Drosophila); Sonic hedgehog protein; Sonic hedgehog protein C-product; Sonic hedgehog protein N-product; TPT; TPTPS
Gene Symbols: SHH
Molecular weight: 49,607 Da
Basal Isoelectric point: 8.09  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SHH

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K32‑ac GPGRGFGkRRHPkKL
0 1 K37‑ac FGkRRHPkKLTPLAY
0 1 S190 CSVKAENSVAAKSGG
0 1 Y253‑p DGAKKVFyVIETREP
0 1 Y316‑p VRPGQRVyVVAERDG
  mouse

 
K33 GPGRGFGKRRHPKKL
K38 FGKRRHPKKLTPLAY
S191‑p CSVKAENsVAAKSGG
Y254 EGAKKVFYVIETLEP
Y302 VRPGQRVYVVAERGG
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