Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
AQP2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
AQP2 Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Expressed in renal collecting tubules. Belongs to the MIP/aquaporin (TC 1.A.8) family. Note: This description may include information from UniProtKB.
Protein type: Channel, misc.; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family; Membrane protein, integral
Chromosomal Location of Human Ortholog: 12q12-q13
Cellular Component: apical plasma membrane; basolateral plasma membrane; Golgi apparatus; integral to plasma membrane; membrane; plasma membrane; recycling endosome
Molecular Function: glycerol channel activity; glycerol transmembrane transporter activity; water channel activity; water transporter activity
Biological Process: cellular response to water deprivation; cellular water homeostasis; excretion; glycerol transport; renal water homeostasis; renal water transport; water transport
Disease: Diabetes Insipidus, Nephrogenic, Autosomal
Reference #:  P41181 (UniProtKB)
Gene Symbols: AQP2
Molecular weight: 28,837 Da
Basal Isoelectric point: 6.44  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AQP2

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
intracellular localization: S256‑p, K270‑ub
molecular association, regulation: S256‑p
phosphorylation: K270‑ub
protein degradation: K270‑ub

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 K228‑ub YVLFPPAkSLSERLA
0 1 K238 SERLAVLKGLEPDTD
57 7 S256‑p REVRRRQsVELHsPQ
20 7 S261‑p RQsVELHsPQsLPRG
13 6 S264‑p VELHsPQsLPRGtkA
17 3 T269‑p PQsLPRGtkA_____
5 0 K270‑ub QsLPRGtkA______
  mouse

 
K228 YLLFPSTKSLQERLA
K238‑ub QERLAVLkGLEPDTD
S256‑p REVRRRQsVELHsPQ
S261‑p RQsVELHsPQsLPRG
S264‑p VELHsPQsLPRGskA
S269‑p PQsLPRGskA_____
K270‑ub QsLPRGskA______
  rat

 
K228 YLLFPSAKSLQERLA
K238 QERLAVLKGLEPDTD
S256‑p REVRRRQsVELHsPQ
S261‑p RQsVELHsPQsLPRG
S264‑p VELHsPQsLPRGskA
S269‑p PQsLPRGskA_____
K270‑ub QsLPRGskA______
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.