Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
AMSH (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
AMSH an adaptor protein involved in cytokine signal transduction the JAK-STAT cascade. Binds to the SH3 domain of the signal-transducing adaptor molecule STAM (signal transducing adaptor molecule). May play a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Note: This description may include information from UniProtKB.
Protein type: Protease; Ubiquitin-specific protease; EC 3.4.19.-; EC 3.1.2.15
Chromosomal Location of Human Ortholog: 2p13.1
Cellular Component: cleavage furrow; cytoplasm; nucleoplasm; nucleus; plasma membrane
Molecular Function: protein binding; protein domain specific binding; ubiquitin-specific protease activity
Biological Process: cytokinesis after mitosis; JAK-STAT cascade; negative regulation of phosphoinositide 3-kinase cascade; negative regulation of Ras protein signal transduction; positive regulation of cell proliferation; protein deubiquitination
Disease: Microcephaly-capillary Malformation Syndrome
Reference #:  O95630 (UniProtKB)
Alt. Names/Synonyms: AMSH; Associated molecule with the SH3 domain of STAM; Endosome-associated ubiquitin isopeptidase; MGC126516; MGC126518; STABP; STAM binding protein; STAM-binding protein; STAMBP
Gene Symbols: STAMBP
Molecular weight: 48,077 Da
Basal Isoelectric point: 5.89  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AMSH

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 1 S2‑p ______MsDHGDVSL
0 1 S19‑p EDRVRALsQLGSAVE
0 1 Y36 EDIPPRRYFRsGVEI
0 1 F37 DIPPRRYFRsGVEII
0 1 S39‑p PPRRYFRsGVEIIRM
1 20 S48‑p VEIIRMAsIYSEEGN
0 1 K88‑ac KSAVIPEkKDTVKKL
0 1 K96‑ub KDTVKKLkEIAFPkA
0 1 K102‑sm LkEIAFPkAEELkAE
0 4 K107‑ub FPkAEELkAELLKRY
0 2 Y118 LKRYTKEYTEYNEEK
0 1 K153‑ac KQRVAQQkQQQLEQE
0 2 K153‑ub KQRVAQQkQQQLEQE
0 1 K176‑ub IRNQELEkERLkIVQ
0 1 K180‑ub ELEkERLkIVQEFGK
0 1 L211 SLDVFPTLTVSSIQP
0 1 S214 VFPTLTVSSIQPSDC
1 1 S243‑p SLKPGALsNsEsIPT
1 0 S245‑p KPGALsNsEsIPTID
1 2 S247‑p GALsNsEsIPTIDGL
0 1 T297 MRNEFTITHVLIPKQ
0 1 K378‑ub FQETGFFkLTDHGLE
0 2 S399‑p QKGFHPHsKDPPLFC
  mouse

 
S2 ______MSDHGDVSL
S19 QDRVRILSQLGSAVE
Y36‑p EDIPPRRyyRSGVEI
Y37‑p DIPPRRyyRSGVEII
S39 PPRRyyRSGVEIIRM
S48 VEIIRMASVYSEEGN
K88 KSAIIPEKKDAVKKL
K96 KDAVKKLKSVAFPKA
K102 LKSVAFPKAEELkTE
K107‑ub FPKAEELkTELLRRY
Y118 LRRYTKEYEQYKERK
K153 KQRVAQQKQKQLEQE
K153 KQRVAQQKQKQLEQE
K176 IQRQELEKERLKIVQ
K180 ELEKERLKIVQEFGK
S211‑p CVDVAPSsPFsPTQT
S214‑p VAPSsPFsPTQTPDC
S243 SLKPGALSVIENVPT
I245 KPGALSVIENVPTIE
N247 GALSVIENVPTIEGL
T297‑p MRNEFTItHVLIPRQ
K378 FQETGFFKLTDYGLQ
G399 QKGFHPHGRDPPLFC
  rat

 
S2 ______MSDHADVSL
S19 QDRVRILSQLGSAVE
Y36 EDIPPRRYFRSGVEI
F37 DIPPRRYFRSGVEII
S39 PPRRYFRSGVEIIRM
S48 VEIIRMASIYSEEGN
K88 KSAIIPEKKDAVKKL
K96 KDAVKKLKNVAFPKA
K102 LKNVAFPKAEELKTE
K107 FPKAEELKTELLKRY
Y118‑p LKRYTKEyEQYKERK
K153 KQRVAQQKQKQLEQE
K153 KQRVAQQKQKQLEQE
K176 IQKQELEKERLKIVQ
K180 ELEKERLKIVQEFGK
S211 CVDVAPSSPFSPTQT
S214 VAPSSPFSPTQTSDC
S243 SLKPGALSVIENVPT
I245 KPGALSVIENVPTIE
N247 GALSVIENVPTIEGL
T297 MRNEFTITHVLIPRQ
K378 FQETGFFKLTDYGLQ
G399 QKGFHPHGRDPPLFC
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.