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Protein Page:
S100A4 (human)

Overview
S100A4 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Protein type: Calcium-binding; Cell development/differentiation
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: extracellular space; nucleus; perinuclear region of cytoplasm
Molecular Function: protein binding; RAGE receptor binding
Biological Process: epithelial to mesenchymal transition; positive regulation of I-kappaB kinase/NF-kappaB cascade
Reference #:  P26447 (UniProtKB)
Alt. Names/Synonyms: 18A2; 42A; Calvasculin; CAPL; fibroblast-specific protein-1; FSP1; leukemia multidrug resistance associated protein; malignant transformation suppression 1; Metastasin; MTS1; P9KA; PEL98; Placental calcium-binding protein; Protein Mts1; Protein S100-A4; S100 calcium binding protein A4; S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog); S100 calcium-binding protein A4; S100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog); S100A4; S10A4
Gene Symbols: S100A4
Molecular weight: 11,729 Da
Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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S100A4

Protein Structure Not Found.
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