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Protein Page:
TRAIL (human)

Overview
TRAIL Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. Homotrimer. Widespread; most predominant in spleen, lung and prostate. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cytokine
Chromosomal Location of Human Ortholog: 3q26
Cellular Component: extracellular region; extracellular space; integral to plasma membrane
Molecular Function: cytokine activity; metal ion binding; protein binding; receptor binding; tumor necrosis factor receptor binding
Biological Process: apoptosis; caspase activation; cell surface receptor linked signal transduction; cell-cell signaling; immune response; positive regulation of apoptosis; positive regulation of caspase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transduction
Reference #:  P50591 (UniProtKB)
Alt. Names/Synonyms: Apo-2 ligand; Apo-2L; APO2L; CD253; Protein TRAIL; TL2; TNF-related apoptosis inducing ligand TRAIL; TNF-related apoptosis-inducing ligand; TNF10; TNFSF10; TRAIL; tumor necrosis factor (ligand) family, member 10; tumor necrosis factor (ligand) superfamily, member 10; tumor necrosis factor apoptosis-inducing ligand splice variant delta; Tumor necrosis factor ligand superfamily member 10
Gene Symbols: TNFSF10
Molecular weight: 32,509 Da
Basal Isoelectric point: 7.01  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TRAIL

Protein Structure Not Found.
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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S133‑p ITGTRGRsNtLSSPN
0 1 T135‑p GTRGRsNtLSSPNSK
0 2 Y213‑p MVQYIYKytSYPDPI
0 2 T214‑p VQYIYKytSYPDPIL
0 1 S215 QYIYKytSYPDPILL
0 3 S225‑p DPILLMKsARNSCWS
  mouse

 
S137 ITGITRRSNSALIPI
S139 GITRRSNSALIPISK
Y223‑p LVQYIYKytsYPDPI
T224‑p VQYIYKytsYPDPIV
S225‑p QYIYKytsYPDPIVL
S235 DPIVLMKSARNSCWS
  rat

 
S137 ITGITRRSNLALIPI
L139 GITRRSNLALIPISK
Y223 MVQYIYKYTSYPDPI
T224 VQYIYKYTSYPDPIL
S225 QYIYKYTSYPDPILL
S235 DPILLMKSARNSCWS
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