SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Interacts with IGF1 receptor, prolactin receptor and growth hormone (GH) receptor. Associates with the Elongin BC complex. By a subset of cytokines, including EPO/erythropoietin and CSF2/GM-CSF. High expression in heart, placenta, lung, kidney and prostate. Note: This description may include information from UniProtKB.
Molecular Function: growth hormone receptor binding; insulin-like growth factor receptor binding; JAK pathway signal transduction adaptor activity; protein binding; protein kinase inhibitor activity; SH3/SH2 adaptor activity
Biological Process: cellular response to hormone stimulus; cytokine and chemokine mediated signaling pathway; JAK-STAT cascade; negative regulation of apoptosis; negative regulation of insulin receptor signaling pathway; negative regulation of JAK-STAT cascade; negative regulation of protein kinase activity; positive regulation of signal transduction; protein ubiquitination; regulation of cell growth; regulation of signal transduction; response to estradiol stimulus
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.