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Protein Page:
14-3-3 eta (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
14-3-3 eta a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 22q12.3
Cellular Component: cytoplasm; cytoplasmic vesicle membrane; cytosol; plasma membrane
Molecular Function: enzyme binding; glucocorticoid receptor binding; insulin-like growth factor receptor binding; protein binding; protein domain specific binding; protein heterodimerization activity; sodium channel regulator activity
Biological Process: glucocorticoid catabolic process; glucocorticoid receptor signaling pathway; intracellular protein transport; negative regulation of dendrite morphogenesis; positive regulation of transcription, DNA-dependent; regulation of neuron differentiation; regulation of sodium ion transport; regulation of synaptic plasticity; substantia nigra development
Reference #:  Q04917 (UniProtKB)
Alt. Names/Synonyms: 14-3-3 eta; 14-3-3 protein eta; 1433F; Protein AS1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; YWHA1; YWHAH
Gene Symbols: YWHAH
Molecular weight: 28,219 Da
Basal Isoelectric point: 4.76  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  G2/M DNA Damage Checkpoint  |  Growth And Differentiation Control by MAPKs  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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14-3-3 eta

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S25‑p ERYDDMAsAMKAVTE
0 4 S38‑p TELNEPLsNEDRNLL
0 22 S46‑p NEDRNLLsVAykNVV
0 9 Y49‑p RNLLsVAykNVVGAR
0 7 K50‑ac NLLsVAykNVVGARR
0 151 K50‑ub NLLsVAykNVVGARR
2 9 S59‑p VVGARRSsWRVISsI
0 2 S64 RSsWRVISsIEQkTM
0 5 S65‑p SsWRVISsIEQkTMA
0 2 K69‑ac VISsIEQkTMADGNE
0 2 K69‑ub VISsIEQkTMADGNE
0 1 K69‑sc VISsIEQkTMADGNE
0 2 K77 TMADGNEKKLEKVKA
0 11 K77‑ub TMADGNEkKLEKVKA
0 2 K110‑ub LLDKFLIkNCNDFQY
0 10 Y117 kNCNDFQYEskVFyL
0 1 S119‑p CNDFQYEskVFyLkM
0 7 K120‑ac NDFQYEskVFyLkMk
0 1 K120 NDFQYEsKVFyLkMk
0 1 Y123‑p QYEskVFyLkMkGDY
0 6 K125‑ac EskVFyLkMkGDYyR
0 74 K125‑ub EskVFyLkMkGDYyR
0 10 K127‑ub kVFyLkMkGDYyRYL
0 34 Y131‑p LkMkGDYyRYLAEVA
0 1 S139‑p RYLAEVAsGEkkNSV
0 2 K142‑ac AEVAsGEkkNSVVEA
0 11 K142‑ub AEVAsGEkkNSVVEA
0 3 K143‑ub EVAsGEkkNSVVEAS
0 1 Y154‑p VEASEAAyKEAFEIS
0 3 T168‑p SKEQMQPtHPIRLGL
  mouse

 
S25 ERYDDMASAMKAVTE
S38‑p TELNEPLsNEDRNLL
S46‑p NEDRNLLsVAykNVV
Y49‑p RNLLsVAykNVVGAR
K50‑ac NLLsVAykNVVGARR
K50‑ub NLLsVAykNVVGARR
S59‑p VVGARRSsWRVIssI
S64‑p RSsWRVIssIEQkTM
S65‑p SsWRVIssIEQkTMA
K69 VIssIEQKTMADGNE
K69‑ub VIssIEQkTMADGNE
K69 VIssIEQKTMADGNE
K77‑ac TMADGNEkKLEKVKA
K77‑ub TMADGNEkKLEKVKA
K110‑ub LLDKFLIkNCNDFQy
Y117‑p kNCNDFQyESkVFYL
S119 CNDFQyESkVFYLkM
K120 NDFQyESKVFYLkMk
K120‑ub NDFQyESkVFYLkMk
Y123 QyESkVFYLkMkGDY
K125‑ac ESkVFYLkMkGDYyR
K125‑ub ESkVFYLkMkGDYyR
K127‑ub kVFYLkMkGDYyRYL
Y131‑p LkMkGDYyRYLAEVA
S139 RYLAEVASGEkkNSV
K142 AEVASGEKkNSVVEA
K142‑ub AEVASGEkkNSVVEA
K143‑ub EVASGEkkNSVVEAS
Y154 VEASEAAYKEAFEIS
T168 SKEHMQPTHPIRLGL
  rat

 
S25 ERYDDMASAMKAVTE
S38 TELNEPLSNEDRNLL
S46‑p NEDRNLLsVAYkNVV
Y49 RNLLsVAYkNVVGAR
K50‑ac NLLsVAYkNVVGARR
K50‑ub NLLsVAYkNVVGARR
S59‑p VVGARRSsWRVIsSI
S64‑p RSsWRVIsSIEQkTM
S65 SsWRVIsSIEQkTMA
K69‑ac VIsSIEQkTMADGNE
K69 VIsSIEQKTMADGNE
K69 VIsSIEQKTMADGNE
K77‑ac TMADGNEkKLEKVKA
K77‑ub TMADGNEkKLEKVKA
K110 LLDKFLIKNCNDFQy
Y117‑p KNCNDFQyESKVFYL
S119 CNDFQyESKVFYLkM
K120 NDFQyESKVFYLkMk
K120 NDFQyESKVFYLkMk
Y123 QyESKVFYLkMkGDY
K125‑ac ESKVFYLkMkGDYYR
K125‑ub ESKVFYLkMkGDYYR
K127‑ub KVFYLkMkGDYYRYL
Y131 LkMkGDYYRYLAEVA
S139 RYLAEVASGEkKNSV
K142 AEVASGEKKNSVVEA
K142‑ub AEVASGEkKNSVVEA
K143 EVASGEkKNSVVEAS
Y154 VEASEAAYKEAFEIS
T168 SKEHMQPTHPIRLGL
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