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Protein Page:
14-3-3 zeta (human)

14-3-3 zeta a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. Phosphorylation apparently disrupts homodimerization. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 8q23.1
Cellular Component: cell-cell adherens junction; cytoplasm; cytoplasmic vesicle membrane; cytosol; extracellular space; focal adhesion; nucleoplasm; nucleus
Molecular Function: protein binding; protein kinase binding; transcription factor binding; ubiquitin protein ligase binding
Biological Process: establishment of Golgi localization; negative regulation of apoptosis; platelet activation; regulation of mRNA stability; signal transduction
Reference #:  P63104 (UniProtKB)
Alt. Names/Synonyms: 14-3-3 protein zeta/delta; 14-3-3 protein/cytosolic phospholipase A2; 14-3-3 zeta; 14-3-3-zeta; 1433Z; KCIP-1; MGC111427; MGC126532; MGC138156; phospholipase A2; Protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide; YWHAZ
Gene Symbols: YWHAZ
Molecular weight: 27,745 Da
Basal Isoelectric point: 4.73  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Apoptosis Regulation  |  G2/M DNA Damage Checkpoint  |  Growth And Differentiation Control by MAPKs  |  Hippo Signaling  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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14-3-3 zeta

Protein Structure Not Found.
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