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Protein Page:
FOXD3 (human)

FOXD3 Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 1p31.3
Cellular Component: nuclear chromatin; nucleoplasm
Molecular Function: transcription factor activity
Biological Process: in utero embryonic development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; somatic stem cell maintenance
Disease: Autoimmune Disease, Susceptibility To, 1
Reference #:  Q9UJU5 (UniProtKB)
Alt. Names/Synonyms: AIS1; forkhead box D3; Forkhead box protein D3; FOXD3; Genesis; HFH2; HNF3/FH transcription factor genesis
Gene Symbols: FOXD3
Molecular weight: 47,630 Da
Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states
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