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Protein Page:
NIPA (human)

NIPA a nuclear protein that interacts with anaplastic lymphoma kinase (ALK). An essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1. Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting cyclin B1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of cyclin B1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. Interacts with the NPM-ALK fusion protein in a tyrosine phosphorylation-dependent manner. Three splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 7q32.2
Cellular Component: nuclear membrane; nucleus
Molecular Function: protein binding; protein kinase binding
Reference #:  Q86WB0 (UniProtKB)
Alt. Names/Synonyms: 1110054L24Rik; hematopoietic stem/progenitor cell protein 216; hNIPA; HSPC216; NIPA; nuclear interacting partner of anaplastic lymphoma kinase (ALK); nuclear interaction partner of ALK; Nuclear-interacting partner of ALK; Nuclear-interacting partner of anaplastic lymphoma kinase; ZC3HC1; Zinc finger C3HC-type protein 1; zinc finger, C3HC type 1; zinc finger, C3HC-type containing 1
Gene Symbols: ZC3HC1
Molecular weight: 55,262 Da
Basal Isoelectric point: 5.44  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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