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Protein Page:
Talin-1 (human)

Talin-1 a cytoskeletal protein which is concentrated in areas of cell-substratum and cell-cell contacts. This protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9p13
Cellular Component: cell-cell adherens junction; cytoplasm; cytosol; extracellular region; focal adhesion; intercellular junction; microtubule organizing center; plasma membrane; ruffle
Molecular Function: integrin binding; LIM domain binding; protein binding; vinculin binding
Biological Process: intercellular junction assembly; muscle contraction; platelet degranulation
Reference #:  Q9Y490 (UniProtKB)
Alt. Names/Synonyms: KIAA1027; talin 1; Talin-1; TLN; TLN1
Gene Symbols: TLN1
Molecular weight: 269,767 Da
Basal Isoelectric point: 5.77  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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