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Protein Page:
GFAP (human)

Overview
GFAP a class-III intermediate filament protein. A cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. An additional transcript variant isoform has been described, but its full length sequence has not been determined. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: cytoplasm; cytosol; intermediate filament cytoskeleton; lysosome
Molecular Function: protein binding
Biological Process: regulation of protein complex assembly
Disease: Alexander Disease
Reference #:  P14136 (UniProtKB)
Alt. Names/Synonyms: FLJ45472; GFAP; Glial fibrillary acidic protein
Gene Symbols: GFAP
Molecular weight: 49,880 Da
Basal Isoelectric point: 5.42  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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GFAP

Protein Structure Not Found.


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