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Protein Page:
CPEB (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CPEB cytoplasmic polyadenylation element binding protein 1. Binds to the protein CPE and drives its polyadenylation. Activated by the protein kinase AurA. Insulin and progesterone stimulate AurA-catalyzed phosphorylation of CPEB in oocytes. Neuronal CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia. Note: This description may include information from UniProtKB.
Protein type: Translation; RNA-binding
Chromosomal Location of Human Ortholog: 15q25.2
Cellular Component: cell junction; cytoplasm; dendrite; neuron projection; nucleoplasm; nucleus; postsynaptic density; postsynaptic membrane; synapse
Molecular Function: metal ion binding; mRNA 3'-UTR binding; nucleotide binding; ribosome binding; translation factor activity, nucleic acid binding; translation repressor activity, nucleic acid binding
Biological Process: cellular response to insulin stimulus; mRNA processing; translation
Reference #:  Q9BZB8 (UniProtKB)
Alt. Names/Synonyms: CEBP; CPE-binding protein 1; CPE-BP1; CPEB; CPEB1; cytoplasmic polyadenylation element binding protein 1; Cytoplasmic polyadenylation element-binding protein 1; FLJ13203; h-CEBP; hCPEB-1; MGC34136; MGC60106
Gene Symbols: CPEB1
Molecular weight: 62,595 Da
Basal Isoelectric point: 7.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CPEB

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S43‑p INAILDNsLDFSRVC
0 1 T52‑p DFSRVCTtPINRGIH
8 0 T172 VRGSRLDTRPILDsR
3 1 S178‑p DTRPILDsRSSSPSD
0 3 S208‑p LISSLRIsPPLPFLS
0 1 K305‑ub QLPPRNYkNPIYSCK
0 1 K347‑ac EWPGKDGkHPRCPPK
  mouse

 
S43 INAILDDSLDFSKVC
T52 DFSKVCTTPINRGIH
T171‑p VRGSRLDtRPILDsR
S177‑p DtRPILDsRSSSPSD
S207‑p LISSLRIsPPLPFLS
K304 QLPPRNYKNPIYSCK
K346 EWPGKDGKHPRCPPK
  rat

 
S43 INAILDDSLDFSKVC
T52 DFSKVCTTPINRGIH
T171‑p VRGSRLDtRPILDSR
S177 DtRPILDSRSSSPSD
S207 LISSLRISPPLPFLS
K304 QLPPRNYKNPIYSCK
K346 EWPGKDGKHPRCPPK
  pig

 
S43 INTILDNSLDFSRVC
T52 DFSRVCTTPINRGIH
T172‑p VRRSRLDtRPILDsR
S178‑p DtRPILDsRSSSPSD
S208 LISSLRISPPLPFLS
K305 QLPPRNYKNPIYSCK
K347 EWPGKDGKHPRCPPK
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