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Protein Page:
CASP9 (rat)

CASP9 a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two isoforms. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC; Protease
Cellular Component: apoptosome; cytoplasm; cytosol; mitochondrion; nucleus
Molecular Function: cysteine-type endopeptidase activity; cysteine-type peptidase activity; peptidase activity; protein binding; protein kinase binding; SH3 domain binding
Biological Process: aging; apoptosis; caspase activation; DNA damage response, signal transduction; DNA damage response, signal transduction resulting in induction of apoptosis; positive regulation of apoptosis; positive regulation of neuron apoptosis; proteolysis; response to antibiotic; response to cobalt ion; response to DNA damage stimulus; response to estradiol stimulus; response to lipopolysaccharide; response to organic cyclic substance; response to UV
Reference #:  Q9JHK1 (UniProtKB)
Alt. Names/Synonyms: 25 kDa caspase-9 dominant negative protein; Apaf3; apoptotic protease activating factor 3; apoptotic protease Mch-6; Casp-9-CTD; Casp9; Casp9_v1; caspase 9, apoptosis-related cysteine peptidase; Caspase 9, isoform CRA_a; Caspase-9; caspase-9 dominant negative form; Caspase-9 long isoform; caspase-9-carboxyl-terminal divergent; Ice-Lap6; Ice-like apoptotic protease 6; Mch6; RNCASP9
Gene Symbols: Casp9
Molecular weight: 50,400 Da
Basal Isoelectric point: 6.04  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Apoptosis Regulation  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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