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Protein Page:
ZO2 (human)

Overview
ZO2 a scaffolding protein of the MAGUK (membrane-associated guanylate kinase) family associated with epithelial tight junctions (TJ). May mediate dynamic changes in the composition of TJs. Plays a role in tight junctions and adherens junctions. Forms homodimers, and heterodimer with ZO-1 and ZO-3. The ZOs shuttle between the TJ and the nucleus, where they may regulate gene expression. Interacts with occluding, UBN1 and scribble. Interacts with SAFB in the nucleus. TJ, or zonula occludens, are the closely associated areas of two cells whose membranes are tightly joined together. They are composed of a branching network of strands, the efficiency of which increases exponentially with the number of strands. The strands associate with transmembrane proteins that bind to similar proteins on adjacent cells, and with submembranous proteins that are anchored to the actin component of the cytoskeleton. Thus, TJs join together the cytoskeletons of adjacent cells. They endow tissues with substantial form, shape and location, enforce cellular polarity, and form barriers to molecules and pathogens. Molecules forming the membranous part of TJs include occludin, claudins, tricellulin and junctional adhesion molecules. These molecules interact with the proteins ZO-1, ZO-2 and ZO-3. Tight junction proteins are involved in the epithelial-mesenchymal transitions (EMT) in tumors. Five isoforms of the human protein are produced by alternative promoters. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues. Note: This description may include information from UniProtKB.. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9q13-q21
Cellular Component: cell junction; cell-cell adherens junction; cytoplasm; cytosol; nucleoplasm; plasma membrane; tight junction
Molecular Function: guanylate kinase activity; protein binding; protein binding, bridging; protein domain specific binding
Biological Process: intestinal absorption
Disease: Cholestasis, Progressive Familial Intrahepatic, 4; Hypercholanemia, Familial
Reference #:  Q9UDY2 (UniProtKB)
Alt. Names/Synonyms: Friedreich ataxia region gene X104 (tight junction protein ZO-2); MGC26306; Tight junction protein 2; tight junction protein 2 (zona occludens 2); tight junction protein ZO 2; Tight junction protein ZO-2; TJP2; X104; ZO2; Zona occludens protein 2; Zonula occludens protein 2
Gene Symbols: TJP2
Molecular weight: 133,958 Da
Basal Isoelectric point: 6.96  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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ZO2

Protein Structure Not Found.
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