a G-protein coupled receptor of the rhodopsin family. This family includes hormone, neurotransmitter and light receptors. Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP. May participate in control of the cell cycle and proliferation. Note: This description may include information from UniProtKB.
Protein type: Receptor, misc.; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Biological Process: aging; cellular ion homeostasis; elevation of cytosolic calcium ion concentration; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); in utero embryonic development; negative regulation of ossification; positive regulation of chemokine production; positive regulation of prostaglandin secretion; positive regulation of smooth muscle cell migration; regulation of vasodilation; sensory perception of pain; wound healing
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.