a member of the ubiquitin family of proteins. Approximately 60% identical to ubiquitin protein.. Activated by an E1-like complex, consisting of App-b1 and Uba3 and then linked to the E2-like enzyme, Ubc12. The major target protein modified by nedd8 is cullin-4a. Down-regulated during the development of brain. Note: This description may include information from UniProtKB.
Molecular Function: protein binding; ubiquitin protein ligase binding
Biological Process: anatomical structure morphogenesis; protein deubiquitination; protein modification process; protein neddylation; proteolysis; transforming growth factor beta receptor signaling pathway; ubiquitin-dependent protein catabolic process