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Protein Page:
USP10 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
USP10 a carboxyl-terminal ubiquitin-processing protease. Ras-GAP SH3 domain-binding protein (G3BP) appears to inhibit its ability to disassemble ubiquitin chains. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin-specific protease; EC 3.4.19.12; RNA-binding; Protease; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 16q24.1
Cellular Component: cytoplasm; early endosome; nucleoplasm; nucleus
Molecular Function: cysteine-type endopeptidase activity; p53 binding; protein binding; ubiquitin-specific protease activity
Biological Process: bypass DNA synthesis; DNA damage response, signal transduction by p53 class mediator; protein deubiquitination; regulation of autophagy
Reference #:  Q14694 (UniProtKB)
Alt. Names/Synonyms: Deubiquitinating enzyme 10; KIAA0190; MGC2621; Ubiquitin carboxyl-terminal hydrolase 10; ubiquitin specific peptidase 10; ubiquitin specific protease 10; Ubiquitin thioesterase 10; Ubiquitin-specific-processing protease 10; UBP10; UBPO; USP10
Gene Symbols: USP10
Molecular weight: 87,134 Da
Basal Isoelectric point: 5.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

USP10

Protein Structure Not Found.


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Sites Implicated In
carcinogenesis, inhibited: T42‑p, S337‑p
cell growth, altered: T42‑p, S337‑p
enzymatic activity, induced: S76‑p
intracellular localization: T42‑p, S337‑p
protein stabilization: T42‑p, S337‑p
ubiquitination: T42‑p, S337‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 4 S5‑p ___MALHsPQYIFGD
0 2 S14‑p QYIFGDFsPDEFNQF
0 2 T24‑p EFNQFFVtPRSSVEL
1 0 T42‑p SGTVLCGtQAVDKLP
0 12 Y54‑p KLPDGQEyQRIEFGV
0 1 S68‑p VDEVIEPsDtLPRtP
0 1 T70‑p EVIEPsDtLPRtPsy
0 8 T74‑p PsDtLPRtPsySISs
1 9 S76‑p DtLPRtPsySISstL
0 4 Y77‑p tLPRtPsySISstLN
0 1 S81‑p tPsySISstLNPQAP
0 3 T82‑p PsySISstLNPQAPE
0 2 T95‑p PEFILGCtASKItPD
0 6 T100‑p GCtASKItPDGITKE
0 4 Y110‑p GITKEASyGSIDCQY
0 22 Y159‑p KKKRPPGyysyLKDG
0 14 Y160‑p KKRPPGyysyLKDGG
0 5 S161‑p KRPPGyysyLKDGGD
0 19 Y162‑p RPPGyysyLKDGGDD
0 1 S203‑p FMGDMPPsVtPRtCN
0 6 T205‑p GDMPPsVtPRtCNsP
0 10 T208‑p PPsVtPRtCNsPQNs
0 33 S211‑p VtPRtCNsPQNstDs
0 2 S215‑p tCNsPQNstDsVsDI
0 4 T216‑p CNsPQNstDsVsDIV
0 2 S218‑p sPQNstDsVsDIVPD
0 1 S220‑p QNstDsVsDIVPDsP
0 25 S226‑p VsDIVPDsPFPGALG
0 8 T263‑p PAEAGRDtLsRTAGA
0 1 S265‑p EAGRDtLsRTAGAQP
0 1 S309‑p VELHTTEsIDLDPTK
0 2 S321‑p PTKPESAsPPADGtG
0 2 T327‑p AsPPADGtGsASGTL
0 2 S329‑p PPADGtGsASGTLPV
1 0 S337‑p ASGTLPVsQPKsWAS
0 2 S341‑p LPVsQPKsWASLFHD
0 1 K350 ASLFHDSKPSSSsPV
0 3 S355‑p DSKPSSSsPVAyVET
0 21 Y359‑p SSSsPVAyVETKysP
0 4 Y364‑p VAyVETKysPPAIsP
0 34 S365‑p AyVETKysPPAIsPL
0 18 S370‑p KysPPAIsPLVSEKQ
0 2 K395‑ub SEDPVAIkIAELLEN
0 3 K408‑ub ENVTLIHkPVSLQPR
0 1 K451 KFIPLYSKVQRPCTS
0 1 K488 PRQALGDKIVRDIRP
0 1 Y503‑p GAAFEPTyIYRLLTV
0 1 K512‑ub YRLLTVNkSSLSEkG
0 1 K518‑ub NkSSLSEkGRQEDAE
0 1 Y527‑p RQEDAEEyLGFILNG
0 16 S547‑p LNLKKLLsPsNEKLT
0 6 S549‑p LKKLLsPsNEKLTIs
0 1 S556‑p sNEKLTIsNGPKNHs
0 4 S563‑p sNGPKNHsVNEEEQE
0 5 Q572 NEEEQEEQGEGsEDE
0 95 S576‑p QEEQGEGsEDEWEQV
0 1 T600‑p RQADFVQtPITGIFG
0 2 Y659‑p ARESVQGyTTKTKQE
0 1 S670‑p TKQEVEIsRRVtLEK
0 1 T674‑p VEIsRRVtLEKLPPV
0 1 K677 sRRVtLEKLPPVLVL
0 1 Y691‑p LHLKRFVyEKtGGCQ
0 1 T694‑p KRFVyEKtGGCQKLI
0 1 K702 GGCQKLIKNIEYPVD
0 1 S713‑p YPVDLEIskELLsPG
0 2 K714‑ac PVDLEIskELLsPGV
0 7 S718‑p EIskELLsPGVKNKN
0 1 K780‑ub INQYQVVkPTAERTA
  USP10 iso2  
S53 KRAAALHSPQYIFGD
S62 QYIFGDFSPDEFNQF
T72 EFNQFFVTPRSSVEL
T90 SGTVLCGTQAVDKLP
Y102 KLPDGQEYQRIEFGV
S116 VDEVIEPSDTLPRTP
T118 EVIEPSDTLPRTPSY
T122 PSDTLPRTPSYSISS
S124 DTLPRTPSYSISSTL
Y125 TLPRTPSYSISSTLN
S129 TPSYSISSTLNPQAP
T130 PSYSISSTLNPQAPE
T143 PEFILGCTASKITPD
T148 GCTASKITPDGITKE
Y158 GITKEASYGSIDCQY
Y207 KKKRPPGYYSYLKDG
Y208 KKRPPGYYSYLKDGG
S209 KRPPGYYSYLKDGGD
Y210 RPPGYYSYLKDGGDD
S251 FMGDMPPSVTPRTCN
T253 GDMPPSVTPRTCNSP
T256 PPSVTPRTCNSPQNS
S259 VTPRTCNSPQNSTDS
S263 TCNSPQNSTDSVSDI
T264 CNSPQNSTDSVSDIV
S266 SPQNSTDSVSDIVPD
S268 QNSTDSVSDIVPDSP
S274 VSDIVPDSPFPGALG
T311 PAEAGRDTLSRTAGA
S313 EAGRDTLSRTAGAQP
S357 VELHTTESIDLDPTK
S369 PTKPESASPPADGTG
T375 ASPPADGTGSASGTL
S377 PPADGTGSASGTLPV
S385 ASGTLPVSQPKSWAS
S389 LPVSQPKSWASLFHD
K398 ASLFHDSKPSSSSPV
S403 DSKPSSSSPVAYVET
Y407 SSSSPVAYVETKYSP
Y412 VAYVETKYSPPAISP
S413 AYVETKYSPPAISPL
S418 KYSPPAISPLVSEKQ
K443 SEDPVAIKIAELLEN
K456 ENVTLIHKPVSLQPR
K499 KFIPLYSKVQRPCTS
K536 PRQALGDKIVRDIRP
Y551 GAAFEPTYIYRLLTV
K560 YRLLTVNKSSLSEKG
K566 NKSSLSEKGRQEDAE
Y575 RQEDAEEYLGFILNG
S595 LNLKKLLSPSNEKLT
S597 LKKLLSPSNEKLTIS
S604 SNEKLTISNGPKNHS
S611 SNGPKNHSVNEEEQE
Q620 NEEEQEEQGEGSEDE
S624 QEEQGEGSEDEWEQV
T648 RQADFVQTPITGIFG
Y707 ARESVQGYTTKTKQE
S718 TKQEVEISRRVTLEK
T722 VEISRRVTLEKLPPV
K725 SRRVTLEKLPPVLVL
Y739 LHLKRFVYEKTGGCQ
T742 KRFVYEKTGGCQKLI
K750 GGCQKLIKNIEYPVD
S761 YPVDLEISKELLSPG
K762 PVDLEISKELLSPGV
S766 EISKELLSPGVKNKN
K828 INQYQVVKPTAERTA
  USP10 iso3  
- gap
S18 QYIFGDFSPDEFNQF
T28 EFNQFFVTPRSSVEL
T46 SGTVLCGTQAVDKLP
Y58 KLPDGQEYQRIEFGV
S72 VDEVIEPSDTLPRTP
T74 EVIEPSDTLPRTPSY
T78 PSDTLPRTPSYSISS
S80 DTLPRTPSYSISSTL
Y81 TLPRTPSYSISSTLN
S85 TPSYSISSTLNPQAP
T86 PSYSISSTLNPQAPE
T99 PEFILGCTASKITPD
T104 GCTASKITPDGITKE
Y114 GITKEASYGSIDCQY
Y163 KKKRPPGYYSYLKDG
Y164 KKRPPGYYSYLKDGG
S165 KRPPGYYSYLKDGGD
Y166 RPPGYYSYLKDGGDD
S207 FMGDMPPSVTPRTCN
T209 GDMPPSVTPRTCNSP
T212 PPSVTPRTCNSPQNS
S215 VTPRTCNSPQNSTDS
S219 TCNSPQNSTDSVSDI
T220 CNSPQNSTDSVSDIV
S222 SPQNSTDSVSDIVPD
S224 QNSTDSVSDIVPDSP
S230 VSDIVPDSPFPGALG
T267 PAEAGRDTLSRTAGA
S269 EAGRDTLSRTAGAQP
S313 VELHTTESIDLDPTK
S325 PTKPESASPPADGTG
T331 ASPPADGTGSASGTL
S333 PPADGTGSASGTLPV
S341 ASGTLPVSQPKSWAS
S345 LPVSQPKSWASLFHD
K354 ASLFHDSKPSSSSPV
S359 DSKPSSSSPVAYVET
Y363 SSSSPVAYVETKYSP
Y368 VAYVETKYSPPAISP
S369 AYVETKYSPPAISPL
S374 KYSPPAISPLVSEKQ
K399 SEDPVAIKIAELLEN
K412 ENVTLIHKPVSLQPR
K455 KFIPLYSKVQRPCTS
K492 PRQALGDKIVRDIRP
Y507 GAAFEPTYIYRLLTV
K516 YRLLTVNKSSLSEKG
K522 NKSSLSEKGRQEDAE
Y531 RQEDAEEYLGFILNG
S551 LNLKKLLSPSNEKLT
S553 LKKLLSPSNEKLTIS
S560 SNEKLTISNGPKNHS
S567 SNGPKNHSVNEEEQE
Q576 NEEEQEEQGEGSEDE
S580 QEEQGEGSEDEWEQV
T604 RQADFVQTPITGIFG
Y663 ARESVQGYTTKTKQE
S674 TKQEVEISRRVTLEK
T678 VEISRRVTLEKLPPV
K681 SRRVTLEKLPPVLVL
Y695 LHLKRFVYEKTGGCQ
T698 KRFVYEKTGGCQKLI
K706 GGCQKLIKNIEYPVD
S717 YPVDLEISKELLSPG
K718 PVDLEISKELLSPGV
S722 EISKELLSPGVKNKN
K784 INQYQVVKPTAERTA
  mouse

 
N5 ___MALHNPQYIFGD
S14 QYIFGDFSPDEFNQF
T24 EFNQFFVTPRSSVEL
I41 YSGTLCSIQAEDELP
H53 ELPDGQEHQRIEFGV
S67 VDEVIEPSEGLPPTP
G69 EVIEPSEGLPPTPSY
T73 PSEGLPPTPSYSISS
S75 EGLPPTPSYSISSTL
Y76 GLPPTPSYSISSTLN
S80 TPSYSISSTLNPQAP
T81 PSYSISSTLNPQAPE
T94 PEFILGCTTSKKIPE
I99 GCTTSKKIPEAVEKD
Y109 AVEKDETYSSIDQYP
Y157 KKKRPPGYYSYLKDG
Y158 KKRPPGYYSYLKDGG
S159 KRPPGYYSYLKDGGE
Y160 RPPGYYSYLKDGGED
P200 EFMDVLPPVMPRtCD
M202 MDVLPPVMPRtCDsP
T205‑p LPPVMPRtCDsPQNP
S208‑p VMPRtCDsPQNPVDF
P212 tCDsPQNPVDFISGP
V213 CDsPQNPVDFISGPV
F215 sPQNPVDFISGPVPD
S217 QNPVDFISGPVPDsP
S223‑p ISGPVPDsPFPRTLG
S256 QPCLPADSLLRTAGT
L258 CLPADSLLRTAGTQP
G302 AELHTDEGADLDPAK
S314 PAKPESQSPPAESAL
A320 QSPPAESALsASGAI
S322‑p PPAESALsASGAIPI
S330 ASGAIPISQPAKSWA
S335 PISQPAKSWASLFHD
K344‑ac ASLFHDSkPSASSPM
S349 DSkPSASSPMAYVET
Y353 SASSPMAYVETKCsP
C358 MAYVETKCsPPVPsP
S359‑p AYVETKCsPPVPsPL
S364‑p KCsPPVPsPLASEKQ
K389 SEDPVAIKIAELLET
K402‑ub ETVTLIHkPVSLQPR
K445‑ub KFIPLYSkVQRPCTS
K482‑ac PRQALGDkIVRDIRP
Y497 GAAFEPTYIYRLLTV
K506 YRLLTVIKSSLSEKG
K512 IKSSLSEKGRQEDAE
Y521 RQEDAEEYLGFILNG
S541‑p LSLKKLLsPtHEKHS
T543‑p LKKLLsPtHEKHSVS
S550 tHEKHSVSNGPRSDL
L557 SNGPRSDLIEDEELE
T566‑p EDEELEDtGKGsEDE
S570‑p LEDtGKGsEDEWEQV
T594 RQADFVQTPITGIFG
Y653 ARESVQGYTTKTKQE
S664 TKQEVEVSRRVTLEk
T668 VEVSRRVTLEkLPPV
K671‑ub SRRVTLEkLPPVLVL
Y685 LHLKRFVYEKTGGCQ
T688 KRFVYEKTGGCQKLV
K696‑ub GGCQKLVkNIDYPVD
S707 YPVDLEISRELLSPG
R708 PVDLEISRELLSPGI
S712 EISRELLSPGIKNKN
K774 INQYQVVKPPADRTA
  rat

 
N5 ___MALHNPQYIFGD
S14 QYIFGDFSPDEFNQF
T24 EFNQFFVTPRSSVEL
I41 YSGTQCGIQAEEELL
H53 ELLDGQEHQRIEFGV
S67 VDEVIEPSDGLQRAP
G69 EVIEPSDGLQRAPSY
A73 PSDGLQRAPSYSISS
S75 DGLQRAPSYSISSTL
Y76 GLQRAPSYSISSTLN
S80 APSYSISSTLNPQAP
T81 PSYSISSTLNPQAPE
P94 PEFILGCPTSKKTPD
T99 GCPTSKKTPDDIEKD
Y109 DIEKDETYSSIDQYP
Y157 KKKRPPGYYSYLKDG
Y158 KKRPPGYYSYLKDGS
S159 KRPPGYYSYLKDGSE
Y160 RPPGYYSYLKDGSEE
S201 FMVDMLPSVMPRtCD
M203 VDMLPSVMPRtCDsP
T206‑p LPSVMPRtCDsPQNP
S209‑p VMPRtCDsPQNPMDL
P213 tCDsPQNPMDLISDP
M214 CDsPQNPMDLISDPV
L216 sPQNPMDLISDPVPD
S218 QNPMDLISDPVPDSP
S224 ISDPVPDSPFPRTLG
N257 QPCLPTDNLLRTAVT
L259 CLPTDNLLRTAVTQP
S304 VELHTDESADLDPAK
S316 PAKPESQSPPAESAL
A322 QSPPAESALSVSGAI
S324 PPAESALSVSGAISI
S332 VSGAISISQPAKSWA
S337 SISQPAKSWASLFHD
K346 ASLFHDSKPSSSSPV
S351 DSKPSSSSPVAYVET
Y355 SSSSPVAYVETKCsP
C360 VAYVETKCsPPVPSP
S361‑p AYVETKCsPPVPSPL
S366 KCsPPVPSPLASEKQ
K391 SEDPVAIKIAELLET
K404 ETVTLVHKPVSLQPR
K447 KFIPLYSKVQRPCTS
K484 PRQALGDKIVRDIRP
Y499 GAAFEPTYIYRLLTV
K508 YRLLTVIKSSLSEKG
K514 IKSSLSEKGRQEDAE
Y523 RQEDAEEYLGFILNG
S543 LSLKKLLSPTHEKHS
T545 LKKLLSPTHEKHSVS
S552 THEKHSVSNGPGSHL
L559 SNGPGSHLIEDEELE
T568‑p EDEELEDtGEGsEDE
S572‑p LEDtGEGsEDEWEQV
T596 RQADFVQTPITGIFG
Y655 ARESVQGYTTKTKQE
S666 TKQEVEVSRRVTLEK
T670 VEVSRRVTLEKLPPV
K673 SRRVTLEKLPPVLVL
Y687 LHLKRFVYEKTGGCQ
T690 KRFVYEKTGGCQKLV
K698 GGCQKLVKNIEYPVD
S709 YPVDLEISRELLSPG
R710 PVDLEISRELLSPGV
S714 EISRELLSPGVKNKN
R776 INQYQVVRPSADRTA
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