tuberous sclerosis protein 1 (TSC1). May have tumor suppressor activity. Together with tuberin (TSC2), inhibits mammalian target of rapamycin (mTOR)-mediated signaling to eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase. Regulated by the phosphatidylinositol 3-kinase/Akt pathway and phosphorylation of tuberin. Phosphorylated by cyclin-dependent kinase 1/cyclin B during the cell cycle. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Tumor suppressor
Cellular Component: actin filament; cell cortex; cytoplasm; cytosol; lamellipodium; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; TSC1-TSC2 complex
Molecular Function: chaperone binding; GTPase regulator activity; protein binding; protein N-terminus binding
Biological Process: adult locomotory behavior; cell cycle arrest; cell-matrix adhesion; negative regulation of cell proliferation; negative regulation of insulin receptor signaling pathway; negative regulation of macroautophagy; negative regulation of TOR signaling pathway; negative regulation of translation; positive regulation of focal adhesion formation; protein stabilization; regulation of cell cycle; regulation of cell-matrix adhesion; regulation of phosphoprotein phosphatase activity; regulation of stress fiber formation; regulation of translation; response to insulin stimulus; rRNA export from nucleus