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Protein Page:
KI-67 (human)

KI-67 a protein that may be a marker of proliferating cells, involved in chromatin compaction. Its expression is altered in many tumor types including osteosarcomas, histiocytomas, prostate, breast and esophageal cancers. Mutated in colon, cervical and lung cancers. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Nucleolus
Chromosomal Location of Human Ortholog: 10q26.2
Cellular Component: condensed chromosome; membrane; nucleolus; nucleus
Molecular Function: protein binding; protein C-terminus binding
Biological Process: cell proliferation; regulation of chromosome segregation; regulation of mitosis
Reference #:  P46013 (UniProtKB)
Alt. Names/Synonyms: antigen identified by monoclonal antibody Ki-67; Antigen KI-67; KI67; KIA; MKI67; proliferation-related Ki-67 antigen
Gene Symbols: MKI67
Molecular weight: 358,694 Da
Basal Isoelectric point: 9.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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