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Protein Page:
VEGFC (human)

Overview
VEGFC Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. Homodimer; non-covalent and antiparallel. Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte. Belongs to the PDGF/VEGF growth factor family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted; Cell cycle regulation; Cytokine
Chromosomal Location of Human Ortholog: 4q34.3
Cellular Component: extracellular region; extracellular space; membrane
Molecular Function: chemoattractant activity; growth factor activity; protein binding; vascular endothelial growth factor receptor 3 binding
Biological Process: angiogenesis; blood coagulation; induction of positive chemotaxis; morphogenesis of embryonic epithelium; negative regulation of blood pressure; negative regulation of cell proliferation; organ morphogenesis; platelet activation; platelet degranulation; positive chemotaxis; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; positive regulation of epithelial cell proliferation; positive regulation of neuroblast proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein amino acid autophosphorylation; positive regulation of protein secretion; regulation of vascular endothelial growth factor receptor signaling pathway; response to drug; signal transduction; substrate-bound cell migration; vascular endothelial growth factor receptor signaling pathway
Disease: Lymphedema, Hereditary, Id
Reference #:  P49767 (UniProtKB)
Alt. Names/Synonyms: Flt4 ligand; FLT4 ligand DHM; Flt4-L; Vascular endothelial growth factor C; Vascular endothelial growth factor-related protein; VEGF-C; VEGFC; VRP
Gene Symbols: VEGFC
Molecular weight: 46,883 Da
Basal Isoelectric point: 7.77  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

VEGFC

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S101‑p REQANLNsRTEEtIK
0 1 T106‑p LNsRTEEtIKFAAAH
  mouse

 
T97 WQQPTLNTRTGDSVK
S102 LNTRTGDSVKFAAAH
  rat

 
M97 WQQPSLNMRTGDTVK
T102 LNMRTGDTVKLAAAH
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