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Protein Page:
VEGFC (human)

Overview
VEGFC Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. Homodimer; non-covalent and antiparallel. Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte. Belongs to the PDGF/VEGF growth factor family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q34.3
Cellular Component: extracellular region
Molecular Function: chemoattractant activity; protein binding
Biological Process: induction of positive chemotaxis; platelet degranulation; positive regulation of cell proliferation; signal transduction; substrate-bound cell migration; vascular endothelial growth factor receptor signaling pathway
Disease: Lymphedema, Hereditary, Id
Reference #:  P49767 (UniProtKB)
Alt. Names/Synonyms: Flt4 ligand; FLT4 ligand DHM; Flt4-L; Vascular endothelial growth factor C; Vascular endothelial growth factor-related protein; VEGF-C; VEGFC; VRP
Gene Symbols: VEGFC
Molecular weight: 46,883 Da
Basal Isoelectric point: 7.77  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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VEGFC

Protein Structure Not Found.
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