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Protein Page:
PFKP (human)

Overview
PFKP phosphofructokinase, platelet type. An ubiquitous metabolic enzyme involved in the synthesis and degradation of fructose 2,6-bisphosphate. Key control step of glycolysis. An allosteric enzyme activated by ADP, AMP, or fructose bisphosphate and inhibited by ATP or citrate. Activity: ATP D-fructose 6-phosphate = ADP D-fructose 1,6-bisphosphate. The holoenzyme consists of 4 subunits. The liver and muscle enzymes are homo-tetramers of four liver or muscle isoforms, respectively. The red blood cell enzyme consists hetero-tetramers of the muscle and liver isoforms. A subunit composition with a higher proportion of platelet type subunits is found in platelets, brain and fibroblasts. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.1.11; Kinase, other
Chromosomal Location of Human Ortholog: 10p15.3-p15.2
Cellular Component: cell-cell adherens junction; cytoplasm; cytosol; extracellular matrix; membrane; nucleus
Molecular Function: 6-phosphofructokinase activity; protein complex binding
Reference #:  Q01813 (UniProtKB)
Alt. Names/Synonyms: 6-phosphofructokinase type C; 6-phosphofructokinase, platelet type; FLJ40226; K6PP; PFK-C; PFKF; PFKP; Phosphofructo-1-kinase isozyme C; Phosphofructokinase 1; phosphofructokinase, platelet; Phosphofructokinase, platelet type; Phosphohexokinase
Gene Symbols: PFKP
Molecular weight: 85,596 Da
Basal Isoelectric point: 7.5  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PFKP

Protein Structure Not Found.
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