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Protein Page:
MCM2 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MCM2 a mini-chromosome maintenance protein, essential for the initiation of eukaryotic genome replication. Allows DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.12; DNA-binding
Chromosomal Location of Human Ortholog: 3q21
Cellular Component: chromatin; cytoplasm; MCM complex; microtubule cytoskeleton; nuclear chromosome, telomeric region; nuclear origin of replication recognition complex; nucleoplasm; nucleus
Molecular Function: ATP binding; DNA binding; DNA helicase activity; DNA replication origin binding; histone binding; metal ion binding; protein binding
Biological Process: cell cycle; DNA replication; DNA replication initiation; DNA strand elongation during DNA replication; DNA unwinding during replication; G1/S transition of mitotic cell cycle; mitotic cell cycle; nucleosome assembly
Reference #:  P49736 (UniProtKB)
Alt. Names/Synonyms: BM28; CCNL1; cdc19; CDCL1; cell devision cycle-like 1; cyclin-like 1; D3S3194; DNA replication licensing factor MCM2; KIAA0030; MCM2; MCM2 minichromosome maintenance deficient 2, mitotin; MGC10606; minichromosome maintenance complex component 2; minichromosome maintenance deficient 2 (mitotin); Minichromosome maintenance protein 2 homolog; MITOTIN; Nuclear protein BM28
Gene Symbols: MCM2
Molecular weight: 101,896 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MCM2

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S27‑p, S41‑p, S139‑p
cell growth, altered: S40‑p, S53‑p
chromatin organization, altered: S13‑p, S27‑p, S40‑p, S41‑p, S53‑p, S108‑p, S139‑p
activity, induced: S27‑p, S41‑p, S139‑p
intracellular localization: S5‑p
molecular association, regulation: S13‑p, S27‑p, S40‑p, S41‑p, S53‑p, S108‑p, S139‑p

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
2 6 S4‑p ____MAEssEsFtMA
2 5 S5‑p ___MAEssEsFtMAs
2 6 S7‑p _MAEssEsFtMAssP
0 3 T9‑p AEssEsFtMAssPAQ
0 8 S12‑p sEsFtMAssPAQRRR
2 30 S13‑p EsFtMAssPAQRRRG
0 26 N21 PAQRRRGNDPLtssP
0 33 T25‑p RRGNDPLtssPGRss
0 65 S26‑p RGNDPLtssPGRssR
3 135 S27‑p GNDPLtssPGRssRR
1 7 S31‑p LtssPGRssRRtDAL
0 8 S32‑p tssPGRssRRtDALt
0 5 T35‑p PGRssRRtDALtssP
0 25 T39‑p sRRtDALtssPGRDL
7 37 S40‑p RRtDALtssPGRDLP
7 67 S41‑p RtDALtssPGRDLPP
10 18 S53‑p LPPFEDEsEGLLGtE
1 13 T59‑p EsEGLLGtEGPLEEE
0 1 Y81‑p GDGMERDyRAIPELD
0 2 Y90‑p AIPELDAyEAEGLAL
0 10 T106‑p DEDVEELtAsQREAA
11 99 S108‑p DVEELtAsQREAAER
0 1 R126‑m1 QRDREAGrGLGRMRR
0 114 Y137‑p RMRRGLLyDsDEEDE
4 392 S139‑p RRGLLyDsDEEDEER
0 20 D140 RGLLyDsDEEDEERP
0 5 T158‑p RRQVERAtEDGEEDE
0 1 S170‑p EDEEMIEsIENLEDL
0 1 K178‑ub IENLEDLkGHSVREW
0 1 S209‑p FLRTHVDsHGHNVFk
0 2 K216‑ac sHGHNVFkERIsDMC
0 1 K216‑ub sHGHNVFkERIsDMC
2 0 S220‑p NVFkERIsDMCkENR
0 1 K224‑ub ERIsDMCkENREsLV
0 2 S229‑p MCkENREsLVVNYED
0 7 S381‑p QRIRIQEsPGkVAAG
0 1 K384‑ub RIQEsPGkVAAGRLP
0 1 Y418‑p EIELTGIyHNNyDGS
0 1 Y422‑p TGIyHNNyDGSLNTA
0 2 K462‑ub ELTDEDVkMITSLSk
0 1 K469‑ac kMITSLSkDQQIGEk
0 11 K469‑ub kMITSLSkDQQIGEk
0 1 K476 kDQQIGEKIFASIAP
0 1 K476‑ub kDQQIGEkIFASIAP
0 1 S484‑p IFASIAPsIYGHEDI
0 2 K492‑ub IYGHEDIkRGLALAL
0 1 T527‑p LLCGDPGtAkSQFLK
0 1 K529‑ub CGDPGtAkSQFLKYI
0 5 K538‑ub QFLKYIEkVSSRAIF
0 1 K538‑sc QFLKYIEkVSSRAIF
0 2 K591‑ub CLIDEFDkMNDQDRT
0 15 K613‑ub QQSISISkAGIVTSL
0 1 K722‑ub LPQEVLKkYIIYAKE
0 1 K734 AKERVHPKLNQMDQD
0 1 K742‑ac LNQMDQDkVAKMYSD
0 1 K752‑ub KMYSDLRkEsMAtGS
0 2 S754‑p YSDLRkEsMAtGSIP
0 1 T757‑p LRkEsMAtGSIPItV
0 1 T763‑p AtGSIPItVRHIEsM
0 1 S769‑p ItVRHIEsMIRMAEA
0 1 S801‑p AIRVMLEsFIDTQKF
0 1 T857‑p RFGAQQDtIEVPEKD
0 1 K868‑ub PEKDLVDkARQINIH
0 1 S878‑p QINIHNLsAFYDSEL
0 1 K896‑ac NKFSHDLkRKMILQQ
0 1 K896‑ub NKFSHDLkRKMILQQ
8861 : Phospho-MCM2 (Ser139) Antibody
12958 : Phospho-MCM2 (Ser139) (D1Z8X) XP(R) Rabbit mAb
  MCM2 iso4  
S4 ____MAESSESFTMA
S5 ___MAESSESFTMAS
S7 _MAESSESFTMASSP
T9 AESSESFTMASSPAQ
S12 SESFTMASSPAQRRR
S13 ESFTMASSPAQRRRG
N21 PAQRRRGNDPLTSSP
T25 RRGNDPLTSSPGRSS
S26 RGNDPLTSSPGRSSR
S27 GNDPLTSSPGRSSRR
S31 LTSSPGRSSRRTDAL
S32 TSSPGRSSRRTDALT
T35 PGRSSRRTDALTSSP
T39 SRRTDALTSSPGRDL
S40 RRTDALTSSPGRDLP
S41 RTDALTSSPGRDLPP
S53 LPPFEDESEGLLGTE
T59 ESEGLLGTEGPLEEE
Y81 GDGMERDYRAIPELD
Y90 AIPELDAYEAEGLAL
T106 DEDVEELTASQREAG
S108 DVEELTASQREAGRG
R114 ASQREAGRGLLYDSD
Y118 EAGRGLLYDSDEEDE
S120 GRGLLYDSDEEDEER
D121 RGLLYDSDEEDEERP
T139 RRQVERATEDGEEDE
S151 EDEEMIESIENLEDL
K159 IENLEDLKGHSVREW
S190 FLRTHVDSHGHNVFK
K197 SHGHNVFKERISDMC
K197 SHGHNVFKERISDMC
S201 NVFKERISDMCKENR
K205 ERISDMCKENRESLV
S210 MCKENRESLVVNYED
S362 QRIRIQESPGKVAAG
K365 RIQESPGKVAAGRLP
Y399 EIELTGIYHNNYDGS
Y403 TGIYHNNYDGSLNTA
K443 ELTDEDVKMITSLSK
K450 KMITSLSKDQQIGEk
K450 KMITSLSKDQQIGEk
K457‑m1 KDQQIGEkESSRNAS
K457 KDQQIGEKESSRNAS
S534 IFASIAPSIYGHEDI
K542 IYGHEDIKRGLALAL
T577 LLCGDPGTAKSQFLK
K579 CGDPGTAKSQFLKYI
K588 QFLKYIEKVSSRAIF
K588 QFLKYIEKVSSRAIF
K641 CLIDEFDKMNDQDRT
K663 QQSISISKAGIVTSL
K772 LPQEVLKKYIIYAKE
K784 AKERVHPKLNQMDQD
K792 LNQMDQDKVAKMYSD
K802 KMYSDLRKESMATGS
S804 YSDLRKESMATGSIP
T807 LRKESMATGSIPITV
T813 ATGSIPITVRHIESM
S819 ITVRHIESMIRMAEA
S851 AIRVMLESFIDTQKF
T907 RFGAQQDTIEVPEKD
K918 PEKDLVDKARQINIH
S928 QINIHNLSAFYDSEL
K946 NKFSHDLKRKMILQQ
K946 NKFSHDLKRKMILQQ
  mouse

 
S4 ____MAESSESLSAs
S5 ___MAESSESLSAss
S7 _MAESSESLSAssPA
S9 AESSESLSAssPARQ
S11‑p SSESLSAssPARQRR
S12‑p SESLSAssPARQRRR
S21‑p ARQRRRIsDPLtssP
T25‑p RRIsDPLtssPGRsS
S26‑p RIsDPLtssPGRsSR
S27‑p IsDPLtssPGRsSRR
S31‑p LtssPGRsSRRADAL
S32 tssPGRsSRRADALt
A35 PGRsSRRADALtssP
T39‑p SRRADALtssPGRDL
S40‑p RRADALtssPGRDLP
S41‑p RADALtssPGRDLPP
S53‑p LPPFEDEsEGLLGTE
T59 EsEGLLGTEGPMEEE
Y81 GDGMERDYRPIPELD
Y90 PIPELDVYEAEGLAL
T106‑p DEDVEELtAsQREAA
S108‑p DVEELtAsQREAAER
R126 QRDREAGRGLGRMRR
Y137‑p RMRRGLLyDssEEDE
S139‑p RRGLLyDssEEDEER
S140‑p RGLLyDssEEDEERP
T158 RRHVERATEDGEEDE
S170 EDEEMIESIENLEDL
K178 IENLEDLKGHSVREW
S209 FLRTHVDSHGHNVFK
K216 SHGHNVFKERISDMC
K216 SHGHNVFKERISDMC
S220 NVFKERISDMCKENR
K224 ERISDMCKENREsLV
S229‑p MCKENREsLVVNYED
S381 QRIRIQESPGKVAAG
K384 RIQESPGKVAAGRLP
Y418 EIELTGIYHNNYDGS
Y422 TGIYHNNYDGSLNTA
K462 ELTDEDVKMITGLSK
K469 KMITGLSKDQQIGEK
K469 KMITGLSKDQQIGEK
K476 KDQQIGEKIFASIAP
K476 KDQQIGEKIFASIAP
S484 IFASIAPSIYGHEDI
K492 IYGHEDIKRGLALAL
T527 LLCGDPGTAKSQFLK
K529 CGDPGTAKSQFLKYI
K538 QFLKYIEKVSSRAIF
K538 QFLKYIEKVSSRAIF
K591 CLIDEFDKMNDQDRT
K613 QQSISISKAGIVTSL
K722 LPQEVLKKYIIYAKE
K734 AKERVRPKLNQMDQD
K742 LNQMDQDKVARMYSD
K752 RMYSDLRKESMATGS
S754 YSDLRKESMATGSIP
T757 LRKESMATGSIPITV
T763 ATGSIPITVRHIESM
S769 ITVRHIESMIRMAEA
S801 AIRVMMESFIDTQKF
T857 RFGAQQDTIEIPEKD
K868 PEKDLMDKARQINIH
S878 QINIHNLSAFYDSDL
K896 NKFSRDLKRKLILQQ
K896 NKFSRDLKRKLILQQ
8861 : Phospho-MCM2 (Ser139) Antibody
12958 : Phospho-MCM2 (Ser139) (D1Z8X) XP(R) Rabbit mAb
  rat

 
S4 ____MAESSESFsAA
S5 ___MAESSESFsAAS
S7 _MAESSESFsAASsP
S9‑p AESSESFsAASsPAP
S12 SESFsAASsPAPQRR
S13‑p ESFsAASsPAPQRRR
S22‑p APQRRRIsDPLTssP
T26 RRIsDPLTssPGRSS
S27‑p RIsDPLTssPGRSSR
S28‑p IsDPLTssPGRSSRR
S32 LTssPGRSSRRADAL
S33 TssPGRSSRRADALT
A36 PGRSSRRADALTSsP
T40 SRRADALTSsPGRDL
S41 RRADALTSsPGRDLP
S42‑p RADALTSsPGRDLPP
S54‑p LPPFEDEsEGLLGTE
T60 EsEGLLGTEGPVEEE
Y82 GDGMERDYRPIPELD
Y91 PIPELDVYEAEGLAL
T107 DEDVEELTASQREAA
S109 DVEELTASQREAAER
R127 QRDREAGRGLGRMRR
Y138 RMRRGLLYDsDEEDE
S140‑p RRGLLYDsDEEDEER
D141 RGLLYDsDEEDEERP
T159 RRHIERATEDGEEDE
S171 EDEEMIESIENLEDL
K179 IENLEDLKGHSVREW
S210 FLRTHVDSHGHNVFK
K217 SHGHNVFKERISDMC
K217 SHGHNVFKERISDMC
S221 NVFKERISDMCKENR
K225 ERISDMCKENRESLV
S230 MCKENRESLVVNYED
S382 QRIRIQESPGKVAAG
K385 RIQESPGKVAAGRLP
Y419 EIELTGIYHNNYDGS
Y423 TGIYHNNYDGSLNTT
K463 ELTDEDVKMITSLSK
K470 KMITSLSKDQQIGEK
K470 KMITSLSKDQQIGEK
K477 KDQQIGEKIFASIAP
K477 KDQQIGEKIFASIAP
S485 IFASIAPSIYGHEDI
K493 IYGHEDIKRGLALAL
T528 LLCGDPGTAKSQFLK
K530 CGDPGTAKSQFLKYI
K539 QFLKYIEKVSSRAIF
K539 QFLKYIEKVSSRAIF
K592 CLIDEFDKMNDQDRT
K614 QQSISISKAGIVTSL
K723 LPQEVLKKYIIYAKE
K735‑ac AKERVRPkLNQMDQD
K743 LNQMDQDKVARMYSD
K753 RMYSDLRKESMATGS
S755 YSDLRKESMATGSIP
T758 LRKESMATGSIPITV
T764 ATGSIPITVRHIESM
S770 ITVRHIESMIRMAEA
S802 AIRVMLESFIDTQKF
T858 RFGAQQDTIEIPEKD
K869 PEKDLMDKARQINIH
S879 QINIHNLSAFYDSDL
K897 NKFSRDLKRKLILQQ
K897 NKFSRDLKRKLILQQ
8861 : Phospho-MCM2 (Ser139) Antibody
12958 : Phospho-MCM2 (Ser139) (D1Z8X) XP(R) Rabbit mAb
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