a transcriptional activator factor. Contains 1 fork-head domain. May play a role in the control of cell proliferation. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Phosphorylated in M (mitotic) phase. Three splice variant isoforms have been described. Isoform 1 and isoform 2 appear to be the only activators of gene transcription. Isoform 3, found in rat, does not seem to exist in human. Note: This description may include information from UniProtKB.
Molecular Function: DNA binding; protein binding; protein kinase binding; sequence-specific DNA binding; transcription factor activity
Biological Process: anatomical structure morphogenesis; cell cycle; cell differentiation; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA repair; G2/M transition of mitotic cell cycle; liver development; mitotic cell cycle; negative regulation of stress-activated MAPK cascade; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of cell cycle; regulation of cell growth; regulation of cell proliferation; regulation of Ras protein signal transduction; regulation of transcription, DNA-dependent; response to cAMP; transcription from RNA polymerase II promoter; transcription, DNA-dependent; vasculogenesis
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.