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Protein Page:
FOXM1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FOXM1 a transcriptional activator factor. Contains 1 fork-head domain. May play a role in the control of cell proliferation. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Phosphorylated in M (mitotic) phase. Three splice variant isoforms have been described. Isoform 1 and isoform 2 appear to be the only activators of gene transcription. Isoform 3, found in rat, does not seem to exist in human. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: protein binding; protein kinase binding
Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; G2/M transition of mitotic cell cycle; negative regulation of stress-activated MAPK cascade; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of cell cycle; regulation of Ras protein signal transduction
Reference #:  Q08050 (UniProtKB)
Alt. Names/Synonyms: FKHL16; forkhead box M1; Forkhead box protein M1; Forkhead, drosophila, homolog-like 16; forkhead-like 16; Forkhead-related protein FKHL16; FOXM1; FOXM1B; Hepatocyte nuclear factor 3 forkhead homolog 11; HFH-11; HFH11; HNF-3; HNF-3/fork-head homolog 11; INS-1; M-phase phosphoprotein 2; MPHOSPH2; MPM-2 reactive phosphoprotein 2; MPP-2; MPP2; PIG29; TGT3; Transcription factor Trident; TRIDENT; WIN; Winged-helix factor from INS-1 cells
Gene Symbols: FOXM1
Molecular weight: 84,283 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FOXM1

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Sites Implicated In
cell cycle regulation: S730‑p, S739‑p
cell growth, induced: S331‑p, S704‑p
transcription, induced: T600‑p, T611‑p, T620‑p, T627‑p, S638‑p, S672‑p, S704‑p, S730‑p, S739‑p
activity, induced: S331‑p, S704‑p
molecular association, regulation: S331‑p, T600‑p, T611‑p, S704‑p
protein stabilization: T600‑p, T611‑p, T620‑p, T627‑p, S638‑p, S672‑p, S704‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 1 S4‑p ____MKTsPRRPLIL
1 4 S35‑p SEEEPKRsPAQQEsN
0 1 S41‑p RsPAQQEsNQAEASK
1 3 S191‑p IQWLRKMsSDGLGSR
2 1 K201‑sm GLGSRSIkQEMEEKE
2 0 K218‑sm HLEQRQVkVEEPSRP
1 1 S251 MIQFAINSTERKRMT
1 1 T252 IQFAINSTERKRMTL
0 1 K278‑m2 PYFKHIAkPGWkNSI
0 1 K282‑m2 HIAkPGWkNSIRHNL
1 1 S306 TSANGKVSFWTIHPS
2 5 S331‑p FKPLDPGsPQLPEHL
0 1 T354‑p PELRRNMtIktELPL
2 1 K356‑sm LRRNMtIktELPLGA
0 1 T357‑p RRNMtIktELPLGAR
1 0 S376 PLLPRVSSYLVPIQF
0 1 K422‑sm KRVRIAPkVLLAEEG
1 1 K440‑sm LSSAGPGkEEKLLFG
1 2 S451‑p LLFGEGFsPLLPVQT
2 0 K460‑sm LLPVQTIkEEEIQPG
2 0 K478‑sm PHLARPIkVEsPPLE
0 2 S481‑p ARPIkVEsPPLEEWP
2 2 S489‑p PPLEEWPsPAPSFkE
2 0 K495‑sm PsPAPSFkEESSHsW
0 1 S501‑p FkEESSHsWEDSSQs
1 3 S508‑p sWEDSSQsPtPRPKK
1 1 T510‑p EDSSQsPtPRPKKSy
0 1 Y517‑p tPRPKKSySGLRsPt
1 5 S522‑p KSySGLRsPtRCVSE
0 1 T524‑p ySGLRsPtRCVSEML
1 1 S581 ELPFPADSSDPASQL
1 1 S582 LPFPADSSDPASQLS
2 3 T600‑p EVGGPFKtPIkETLP
0 1 K603‑sm GPFKtPIkETLPISS
4 5 T611‑p ETLPISStPSKSVLP
2 21 T620‑p SKSVLPRtPEsWRLt
0 2 S623‑p VLPRtPEsWRLtPPA
1 11 T627‑p tPEsWRLtPPAKVGG
2 4 S638‑p KVGGLDFsPVQTSQG
0 1 S666 LSTTPLQSAPPLEsP
1 2 S672‑p QSAPPLEsPQRLLSS
0 1 S692‑p ISVPFGNssPSDIDV
0 1 S693‑p SVPFGNssPSDIDVP
2 5 S704‑p IDVPKPGsPEPQVSG
0 5 S717‑p SGLAANRsLtEGLVL
0 1 T719‑p LAANRsLtEGLVLDT
1 4 S730‑p VLDTMNDsLSKILLD
2 1 S739‑p SKILLDIsFPGLDED
14170 : Phospho-FoxM1 (Ser35) Antibody
14655 : Phospho-FoxM1 (Thr600) (D9M6G) Rabbit mAb
  FOXM1 iso2  
S4 ____MKTSPRRPLIL
S35 SEEEPKRSPAQQESN
S41 RSPAQQESNQAEASK
S191‑p IQWLRKMsSDGLGSR
K201‑sm GLGSRSIkQEMEEKE
K218‑sm HLEQRQVkVEEPSRP
S251‑p MIQFAINstERKRMT
T252‑p IQFAINstERKRMTL
K278 PYFKHIAKPGWKNSI
K282 HIAKPGWKNSIRHNL
S306‑p TSANGKVsFWTIHPS
- gap
T339 PELRRNMTIkTELPL
K341‑sm LRRNMTIkTELPLGA
T342 RRNMTIkTELPLGAR
S361‑p PLLPRVSsYLVPIQF
K407 KRVRIAPKVLLAEEG
K425 LSSAGPGKEEKLLFG
S436 LLFGEGFSPLLPVQT
K445‑sm LLPVQTIkEEEIQPG
K463‑sm PHLARPIkVESPPLE
S466 ARPIkVESPPLEEWP
S474‑p PPLEEWPsPAPSFkE
K480‑sm PsPAPSFkEESSHSW
S486 FkEESSHSWEDSSQS
S493 SWEDSSQSPTPRPKK
T495 EDSSQSPTPRPKKSY
Y502 TPRPKKSYSGLRSPT
S507 KSYSGLRSPTRCVSE
T509 YSGLRSPTRCVSEML
S566‑p ELPFPADssDPASQL
S567‑p LPFPADssDPASQLS
T585 EVGGPFKTPIKETLP
K588 GPFKTPIKETLPISS
T596‑p ETLPISStPSKSVLP
T605 SKSVLPRTPESWRLT
S608 VLPRTPESWRLTPPA
T612 TPESWRLTPPAKVGG
S623‑p KVGGLDFsPVQTSQG
S651 LSTTPLQSAPPLESP
S657 QSAPPLESPQRLLSS
S677 ISVPFGNSSPSDIDV
S678 SVPFGNSSPSDIDVP
S689 IDVPKPGSPEPQVSG
S702 SGLAANRSLTEGLVL
T704 LAANRSLTEGLVLDT
S715 VLDTMNDSLSKILLD
S724‑p SKILLDIsFPGLDED
14655 : Phospho-FoxM1 (Thr600) (D9M6G) Rabbit mAb
  mouse

 
S4 ____MRTSPRRPLIL
S35 SEEEAKRSPAQPEPA
P41 RSPAQPEPAPAQASQ
S189 IQWLGKMSSDGLGPC
K199 GLGPCSVKQELEEKE
K216 HLEQNRVKVEEPSGV
S249 MIQFAINSTERKRMT
T250 IQFAINSTERKRMTL
K276 PYFKHIAKPGWKNSI
K280 HIAKPGWKNSIRHNL
S304 TSANGKVSFWTIHPS
S329 FKPLEPGSPQSPEHL
T352 PELHRNVTIKTEIPL
K354 LHRNVTIKTEIPLGA
T355 HRNVTIKTEIPLGAR
S374 PLLPRVSSYLEPIQF
K420 KRVRIAPKVLLSSEG
K438 LPATEPPKEEKPLLG
L450 LLGGEGLLPLLPIQS
K459 LLPIQSIKEEEMQPE
K477 AHLERPIKVESPPLE
S480 ERPIKVESPPLEEWP
S488 PPLEEWPSPCASLKE
K494 PSPCASLKEELSNSW
S500 LKEELSNSWEDSSCS
S507 SWEDSSCSPTPKPKK
T509 EDSSCSPTPKPKKSY
Y516 TPKPKKSYCGLKSPT
S521 KSYCGLKSPTRCVSE
T523 YCGLKSPTRCVSEML
S578 AVELLAESSEPAPHL
S579 VELLAESSEPAPHLS
T597 EEGGPFKTPIKETLP
K600 GPFKTPIKETLPVSS
T608 ETLPVSSTPSKSVLS
D617 SKSVLSRDPESWRLT
S620 VLSRDPESWRLTPPA
T624 DPESWRLTPPAKVGG
S635‑p KVGGLDFsPVRTPQG
S663‑p LNTTPLKsGPLFDsP
S669‑p KsGPLFDsPRELLNS
P689 ASDPFGSPPPPHVEG
P690 SDPFGSPPPPHVEGP
S701 VEGPKPGSPELQIPS
S714‑p PSLSANRsLTEGLVL
T716 LSANRsLTEGLVLDT
S727‑p VLDTMNDsLSKILLD
S736 SKILLDISFPGLEED
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