an enzyme that removes ubiquitin from its protein substrates. Binds to the herpes virus protein VMW110 that may therefore modulate its substrate specificity or activity to stabilize viral proteins. Regulates MDM2 and has a dynamic role in the p53-MDM2 pathway. Is reported to deubiquitinate and stabilize p53. Note: This description may include information from UniProtKB.
Protein type: Protease; Ubiquitin-specific protease; EC 220.127.116.11; Ubiquitin conjugating system
Cellular Component: cytosol; nuclear body; nucleoplasm; nucleus; PML body
Molecular Function: cysteine-type endopeptidase activity; p53 binding; protein binding; protein C-terminus binding; transcription factor binding; ubiquitin protein ligase binding; ubiquitin-specific protease activity
Biological Process: DNA repair; inhibition of NF-kappaB transcription factor; maintenance of DNA methylation; multicellular organismal development; nucleotide-excision repair; protein deubiquitination; protein stabilization; regulation of transcription factor activity; transcription-coupled nucleotide-excision repair; ubiquitin-dependent protein catabolic process; viral reproduction
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.