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Protein Page:
Scribble (human)

Scribble may be involved in regulating neuroblast cortical polarity, cell size asymmetry and mitotic spindle asymmetry. A neoplastic tumor suppressor genes in Drosophila melanogaster. May play a role in the suppression of mammalian tumorigenesis. Gene ablation in the mouse causes severe neural tube defects. May be implicated in the etiology of human NTDs. Involved in the regulation of synaptic plasticity and synaptic vesicle dynamics. May be required to sustain synaptic vesicle concentrations at their sites of release. Targeted for ubiquitin-mediated degradation by the HPV E6 oncoprotein. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component: cell junction; cell-cell adherens junction; cytoplasm; intercellular junction; leading edge; nucleoplasm; plasma membrane; postsynaptic membrane; presynaptic membrane
Molecular Function: protein binding
Biological Process: cell migration; cell proliferation; cell-cell adhesion; establishment of apical/basal cell polarity; negative regulation of mitotic cell cycle; neural tube closure; positive chemotaxis; positive regulation of apoptosis; positive regulation of receptor recycling
Reference #:  Q14160 (UniProtKB)
Alt. Names/Synonyms: CRIB1; hScrib; KIAA0147; LAP4; Protein LAP4; Protein scribble homolog; SCRB1; SCRIB; SCRIB1; Scribble; scribbled homolog (Drosophila); VARTUL
Gene Symbols: SCRIB
Molecular weight: 174,885 Da
Basal Isoelectric point: 5.01  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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