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Protein Page:
SAE2 (human)

SAE2 a protein of the ubiquitin-activating E1 family. Acts as a UBL1 E1 ligase. Mediates ATP-dependent activation of UBL1 and formation of a thiolester with a conserved cysteine residue on SAE2. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Ligase; Motility/polarity/chemotaxis; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 19q12
Cellular Component: cytosol; nucleoplasm
Molecular Function: enzyme activator activity; protein binding; protein heterodimerization activity; SUMO activating enzyme activity
Biological Process: protein sumoylation
Reference #:  Q9UBT2 (UniProtKB)
Alt. Names/Synonyms: Anthracycline-associated resistance ARX; ARX; FLJ13058; HRIHFB2115; SAE2; SUMO-1 activating enzyme subunit 2; SUMO-activating enzyme subunit 2; SUMO1 activating enzyme subunit 2; UBA2; UBA2, ubiquitin-activating enzyme E1 homolog; Ubiquitin-like 1-activating enzyme E1B; ubiquitin-like modifier activating enzyme 2; UBLE1B
Gene Symbols: UBA2
Molecular weight: 71,224 Da
Basal Isoelectric point: 5.15  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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