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Protein Page:
SUZ12 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SUZ12 a zinc finger protein. A breakpoint translocation of the cognate gene with JAZF1 has been reported in endometrial stromal sarcoma. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Oncoprotein; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: ESC/E(Z) complex; nucleolus; nucleoplasm; nucleus
Molecular Function: histone methyltransferase activity; methylated histone residue binding; protein binding
Biological Process: negative regulation of cell differentiation; negative regulation of gene expression, epigenetic
Reference #:  Q15022 (UniProtKB)
Alt. Names/Synonyms: ChET 9 protein; CHET9; Chromatin precipitated E2F target 9 protein; JJAZ1; Joined to JAZF1 protein; KIAA0160; Polycomb protein SUZ12; suppressor of zeste 12 homolog (Drosophila); Suppressor of zeste 12 protein homolog; SUZ12
Gene Symbols: SUZ12
Molecular weight: 83,055 Da
Basal Isoelectric point: 8.98  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SUZ12

Protein Structure Not Found.
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Sites Implicated In
molecular association, regulation: S539‑p, S541‑p, S546‑p
ubiquitination: S539‑p, S541‑p, S546‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S20‑p GSGPSAGsGGGGFGG
0 3 S37‑p AVAAATAsGGKSGGG
1 0 K72‑sm GAAVLPVkkPkMEHV
1 0 K73‑sm AAVLPVkkPkMEHVQ
1 0 K75‑sm VLPVkkPkMEHVQAD
0 1 T131‑p RTNIKRKtFKVDDML
0 1 S139‑p FKVDDMLskVEkMkG
0 1 K140‑ac KVDDMLskVEkMkGE
0 1 K140‑sm KVDDMLskVEkMkGE
0 1 K143‑ac DMLskVEkMkGEQES
0 1 K145‑ac LskVEkMkGEQESHS
0 1 S200 HKKRKDVSCPIRQVP
0 1 K246‑ac PSNSHMVkSySLLFR
0 1 Y248‑p NSHMVkSySLLFRVt
0 1 T255‑p ySLLFRVtRPGRREF
0 1 T336‑p KKRATWEtILDGkRL
0 6 K341‑ac WEtILDGkRLPPFET
0 4 K341‑ub WEtILDGkRLPPFET
0 1 K368‑ub WTGETNDkSTAPIAk
0 3 K375‑ub kSTAPIAkPLAtRNs
0 1 T379‑p PIAkPLAtRNsESLH
0 3 S382‑p kPLAtRNsESLHQEN
0 1 S393‑p HQENKPGsVKPTQTI
0 1 K403‑m1 PTQTIAVkESLTTDL
0 1 T412‑p SLTTDLQtRKEKDTP
0 1 K537‑ub VCRPKRTkAsMsEFL
1 4 S539‑p RPKRTkAsMsEFLEs
1 5 S541‑p KRTkAsMsEFLEsED
1 42 S546‑p sMsEFLEsEDGEVEQ
0 2 T570‑p RLYFHSDtCLPLRPQ
0 16 S583‑p PQEMEVDsEDEKDPE
0 1 T596 PEWLREKTITQIEEF
0 2 S604‑p ITQIEEFsDVNEGEK
0 1 S693‑p QKLEKGEsAsPANEE
0 4 S695‑p LEKGEsAsPANEEIT
0 4 S726‑p EKALETDsVSGVSKQ
  mouse

 
S20 GSGPSAGSGGGGFGG
S37 AAVAAAASGGKSGGG
K74 GAAVLPVKKPKMEHV
K75 AAVLPVKKPKMEHVQ
K77 VLPVKKPKMEHVQAD
T133 RTSIKRKTFKVDDML
S141 FKVDDMLSKVEKMKG
K142 KVDDMLSKVEKMKGE
K142 KVDDMLSKVEKMKGE
K145 DMLSKVEKMKGEQES
K147 LSKVEKMKGEQESHS
S202‑p HKKRKDVsCPIRQVP
K248 PSNSHMVKSYSLLFR
Y250 NSHMVKSYSLLFRVT
T257 YSLLFRVTRPGRREF
T338 KKRATWETILDGkRL
K343‑ac WETILDGkRLPPFET
K343‑ub WETILDGkRLPPFET
K370 WTGETNDKSTAPVAk
K377‑ub KSTAPVAkPLATRNS
T381 PVAkPLATRNSESLH
S384 kPLATRNSESLHQEN
S395 HQENKPGSVKPAQTI
K405 PAQTIAVKETLTTEL
T414 TLTTELQTRKEKDNS
K539 VCRPKRTKAsMsEFL
S541‑p RPKRTKAsMsEFLEs
S543‑p KRTKAsMsEFLEsED
S548‑p sMsEFLEsEDGEVEQ
T572‑p RLYFHSDtCLPLRPQ
S585‑p PQEMEVDsEDEKDPE
T598‑p PEWLREKtITQIEEF
S606‑p ITQIEEFsDVNEGEK
S695 QKLEKGESATPSNEE
T697 LEKGESATPSNEEIA
G728 EKALETDGVSGVPKQ
  rat

 
S20 GSGPSAGSGGGGFGG
S38 AVAAAVASGGKSGGG
K71 GAAVLPVKKPKMEHV
K72 AAVLPVKKPKMEHVQ
K74 VLPVKKPKMEHVQAD
T130 RTNIKRKTFKVDDML
S138 FKVDDMLSKVEKMKG
K139 KVDDMLSKVEKMKGE
K139 KVDDMLSKVEKMKGE
K142 DMLSKVEKMKGEQES
K144 LSKVEKMKGEQESHS
S199 HKKRKDVSCPIRQVP
K245 PSNSHMVKSYSLLFR
Y247 NSHMVKSYSLLFRVT
T254 YSLLFRVTRPGRREF
T316 KKRATWETILDGKRV
K321 WETILDGKRVPGQQG
K321 WETILDGKRVPGQQG
N350 LSVEINRNAIILYLC
L354 INRNAIILYLCLIIL
L358 AIILYLCLIILARYF
L361 LYLCLIILARYFIEG
S372 FIEGSLSSIMWVYIA
K381 MWVYIAVKETLTTEM
T390 TLTTEMQTRKEKDTS
K515 VCRPKRTKASMSEFL
S517 RPKRTKASMSEFLEs
S519 KRTKASMSEFLEsED
S524‑p SMSEFLEsEDGEVEQ
T548 RLYFHSDTCLPLRPQ
S561 PQEMEVDSEDEKDPE
T574 PEWLREKTITQIEEF
S582 ITQIEEFSDVNEGEK
S671 QKLEKGESAAPANED
A673 LEKGESAAPANEDIA
G704 EKALETDGVSGVPKQ
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