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Protein Page:
SSRP1 (human)

Overview
SSRP1 a subunit of the chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; RNA-binding; Transcription initiation complex; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 11q12
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: protein binding
Biological Process: RNA elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter
Reference #:  Q08945 (UniProtKB)
Alt. Names/Synonyms: Chromatin-specific transcription elongation factor 80 kDa subunit; cisplatin-DNA SSRP; facilitates chromatin remodeling 80 kDa subunit; Facilitates chromatin transcription complex 80 kDa subunit; Facilitates chromatin transcription complex subunit SSRP1; FACT; FACT 80 kDa subunit; FACT complex subunit SSRP1; FACT80; FACTp80; high mobility group box; hSSRP1; Recombination signal sequence recognition protein 1; SSRP1; structure specific recognition protein 1; Structure-specific recognition protein 1; T160
Gene Symbols: SSRP1
Molecular weight: 81,075 Da
Basal Isoelectric point: 6.45  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SSRP1

Protein Structure Not Found.
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