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Protein Page:
ataxin-1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ataxin-1 spinocerebellar ataxia type 1 (SCA1) protein. Expansion of CAG repeats in the SCA1 gene results in an abnormally long polyglutamine tract in the protein, causing polyglutamine-induced neurodegeneration. 14-3-3 and Akt kinase stabilize both wild-type and mutant forms of ataxin-1. The expansion of the polyglutamine tract may alter this function. Note: This description may include information from UniProtKB.
Protein type: Nuclear export; RNA-binding
Chromosomal Location of Human Ortholog: 6p23
Cellular Component: cytoplasm; intracellular membrane-bound organelle; nuclear inclusion body; nuclear matrix; nuclear RNA export factor complex; nucleoplasm; nucleus
Molecular Function: identical protein binding; poly(rG) binding; poly(U) binding; protein binding; protein C-terminus binding; protein self-association
Biological Process: negative regulation of transcription, DNA-dependent; nuclear export
Disease: Spinocerebellar Ataxia 1
Reference #:  P54253 (UniProtKB)
Alt. Names/Synonyms: ataxin 1; Ataxin-1; ATX1; ATXN1; D6S504E; SCA1; Spinocerebellar ataxia type 1 protein
Gene Symbols: ATXN1
Molecular weight: 86,923 Da
Basal Isoelectric point: 8.49  Predict pI for various phosphorylation states
CST Pathways:  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ataxin-1

Protein Structure Not Found.
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Sites Implicated In
cytoskeletal reorganization: S775‑p
intracellular localization: S775‑p
molecular association, regulation: S775‑p
protein degradation: S775‑p
protein stabilization: S775‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 K16‑sm NECLPPKkREIPATS
0 3 P62 HGGGRHGPAGTSVEL
0 4 S82 IGLHKALSTGLDYsP
0 1 S82 IGLHKALSTGLDYsP
0 8 S88‑p LSTGLDYsPPsAPRS
0 1 S91‑p GLDYsPPsAPRSVPV
1 0 K194‑sm LSQTPGHkAEQQQQQ
1 1 T235‑p SRAPGLItPGsPPPA
1 18 S238‑p PGLItPGsPPPAQQN
0 4 A242 tPGsPPPAQQNQyVH
0 1 Y247‑p PPAQQNQyVHISSsP
0 1 S252 NQyVHISSsPQNtGR
0 3 S253‑p QyVHISSsPQNtGRT
0 2 T257‑p ISSsPQNtGRTASPP
0 1 S312‑p ATKKAESsRLQQAIQ
0 1 S366‑p RHVVVHPsPSDYSSR
0 1 A392 LPNSNTPAADLEVQQ
0 12 S406‑p QATHREAsPsTLNDK
0 1 S408‑p THREAsPsTLNDKSG
1 0 K609‑sm AEISNDLkIDSSTVE
1 0 K609 AEISNDLKIDSSTVE
1 0 K696‑sm NLKNGSVkKGQPVDP
0 1 K709 DPASVLLKHsKADGL
0 4 S711‑p ASVLLKHsKADGLAG
1 0 K745‑sm LSENGELkFPEKMGL
0 1 T769‑p EPSKPAAtRKRRWsA
13 23 S775‑p AtRKRRWsAPESRKL
0 4 S811‑p KICIEGRsNVGK___
  mouse

 
K16 NECLPPKKREIPATS
S62‑p HGGGRHGsAGTSGEH
S81‑p MGLHKALsAGLDYsP
S81‑gl MGLHKALsAGLDYsP
S87‑p LsAGLDYsPPSAPRS
S90 GLDYsPPSAPRSVPT
K193 LSQAPGHKVEPPPQQ
N210 SRAAGLVNPGsPPPP
S213‑p AGLVNPGsPPPPtQQ
T218‑p PGsPPPPtQQNQYIH
Y223 PPtQQNQYIHISssP
S228‑p NQYIHISssPQSsGR
S229‑p QYIHISssPQSsGRA
S233‑p ISssPQSsGRATSPP
S288 STKKAESSRLQQAMQ
S342 RHVVVHPSPADYSSR
S368‑p LPNSSTPsADLEAQQ
S382‑p QTTHREAsPSTLNDK
S384 THREAsPSTLNDKSG
K585 AEISNDLKIDSSTVE
K585‑ub AEISNDLkIDSSTVE
K672 NLKNGSVKKGQPVDP
K685‑ub DPASVLLkQAKTDSL
A687 ASVLLkQAKTDSLAG
K721 LSENGELKFPEKIGL
T745 EPSKPTATRKRRWsA
S751‑p ATRKRRWsAPETRKL
S787‑p KICIEGRsNVGK___
  rat

 
K16 NECLPPKKREIPATS
P62 HGGGRHGPAGTSGEH
S81 MGLHKALSAGLDYSP
S81 MGLHKALSAGLDYSP
S87 LSAGLDYSPPSAPRS
S90 GLDYSPPSAPRSVPT
K193 LSQAPGHKVEPPPQQ
N210 GRAAGLVNPGsPPPt
S213‑p AGLVNPGsPPPtQQN
T217‑p NPGsPPPtQQNQYIH
Y222 PPtQQNQYIHISSSP
S227 NQYIHISSSPQSSGR
S228 QYIHISSSPQSSGRA
S232 ISSSPQSSGRATSPP
S286 STKKAESSRLQQAMQ
S340 RHVVVHPSPADYSSR
S366 LPNSSTPSADLETQQ
S380‑p QATHREAsPSTLNDK
S382 THREAsPSTLNDKSG
K583 AEISNDLKIDSSTVE
K583 AEISNDLKIDSSTVE
K670 NLKNGSVKKGQPVDP
K683 DPASALLKHAKTDSL
A685 ASALLKHAKTDSLAG
K719 LSENGELKFPEKIGL
T743 EPSKPTATRKRRWSA
S749 ATRKRRWSAPETRKL
S785 KICIEGRSNVGK___
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