the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na and K ions across the plasma membrane. This action creates the electrochemical gradient of Na and K, providing the energy for active transport of various nutrients. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 220.127.116.11; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Molecular Function: ADP binding; ankyrin binding; ATP binding; chaperone binding; phosphoinositide 3-kinase binding; phosphoric monoester hydrolase activity; potassium ion binding; protein binding; protein domain specific binding; protein kinase binding; sodium ion binding; sodium:potassium-exchanging ATPase activity
Biological Process: cardiac muscle contraction; cellular potassium ion homeostasis; cellular sodium ion homeostasis; energy coupled proton transport, against electrochemical gradient; establishment and/or maintenance of transmembrane electrochemical gradient; membrane hyperpolarization; negative regulation of glucocorticoid biosynthetic process; negative regulation of heart contraction; positive regulation of heart contraction; positive regulation of striated muscle contraction; potassium ion import; potassium ion transport; regulation of blood pressure; regulation of sodium ion transport; regulation of the force of heart contraction; response to drug; sodium ion transport