a pro-apoptotic member of the BCL-2 protein family. Interacts with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and act as an apoptotic activator. Its expression can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role in neuronal and lymphocyte apoptosis. Transgenic studies in the mouse suggested that this protein functions as an essential initiator of the apoptosis in thymocyte-negative selection. Nineteen alternatively spliced transcript variants of this gene have been reported. Note: This description may include information from UniProtKB.
Molecular Function: dynein binding; microtubule binding; protein binding
Biological Process: B cell apoptosis; B cell homeostasis; cell-matrix adhesion; cellular process regulating host cell cycle in response to virus; DNA damage response, signal transduction resulting in induction of apoptosis; ear development; in utero embryonic development; kidney development; leukocyte homeostasis; lumen formation; lymphocyte homeostasis; male gonad development; mammary gland development; myeloid cell homeostasis; odontogenesis of dentine-containing teeth; pigmentation during development; positive regulation of apoptosis; positive regulation of apoptosis by virus; positive regulation of caspase activity; positive regulation of cell cycle; positive regulation of neuron apoptosis; positive regulation of protein homooligomerization; post-embryonic development; post-embryonic organ morphogenesis; regulation of apoptosis; regulation of organ growth; regulation of pigmentation during development; spermatogenesis; spleen development; T cell homeostasis; thymus development