a pro-apoptotic member of the BCL-2 protein family. Interacts with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and act as an apoptotic activator. Its expression can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role in neuronal and lymphocyte apoptosis. Transgenic studies in the mouse suggested that this protein functions as an essential initiator of the apoptosis in thymocyte-negative selection. Nineteen alternatively spliced transcript variants of this gene have been reported. Note: This description may include information from UniProtKB.
Biological Process: apoptosis; DNA damage response, signal transduction resulting in induction of apoptosis; meiosis I; positive regulation of apoptosis; positive regulation of protein homooligomerization; protein insertion into mitochondrial membrane during induction of apoptosis