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Protein Page:
TLR3 (human)

Overview
TLR3 a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. Most abundantly expressed in placenta and pancreas. Restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection. Acts via MyD88 and TRAF6, leading to the activation of NF-kappaB and the production of type I interferon. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 4q35
Cellular Component: cell surface; cytoplasm; endoplasmic reticulum membrane; endosome membrane; Golgi membrane; integral to plasma membrane; intracellular; lysosomal membrane
Molecular Function: double-stranded RNA binding; identical protein binding; protein binding; receptor activity
Biological Process: defense response to bacterium; defense response to virus; I-kappaB kinase/NF-kappaB cascade; I-kappaB phosphorylation; innate immune response; MyD88-independent toll-like receptor signaling pathway; negative regulation of MyD88-independent toll-like receptor signaling pathway; positive regulation of chemokine production; positive regulation of inflammatory response; positive regulation of interferon-alpha biosynthetic process; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-beta production; positive regulation of interferon-gamma biosynthetic process; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of NF-kappaB import into nucleus; positive regulation of toll-like receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; response to exogenous dsRNA; signal transduction; toll-like receptor 3 signaling pathway; toll-like receptor signaling pathway
Disease: Human Immunodeficiency Virus Type 1, Susceptibility To
Reference #:  O15455 (UniProtKB)
Alt. Names/Synonyms: CD283; TLR3; Toll-like receptor 3
Gene Symbols: TLR3
Molecular weight: 103,829 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TLR3

Protein Structure Not Found.
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Sites Implicated In
transcription, altered: Y759‑p
phosphorylation: Y759‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 - gap
0 1 - gap
0 1 - gap
0 1 Y9 RQTLPCIYFWGGLLP
0 1 - gap
0 1 T29 ASSTTKCTVSHEVAD
0 1 T72‑p RLPAANFtRYSQLTS
0 1 T86 SLDVGFNTISKLEPE
0 3 S205‑p SLKKLELssNQIKEF
0 3 S206‑p LKKLELssNQIKEFS
0 4 S350‑p LPKIDDFsFQWLKCL
0 1 Y383‑p TGLINLKyLSLSNSF
0 1 T391‑p LSLSNSFtsLRTLTN
0 1 S392‑p SLSNSFtsLRTLTNE
4 0 Y759‑p EQFEYAAyIIHAYKD
0 1 T818‑p RKIIFVItHHLLKDP
1 0 Y858‑p FLEEIPDyKLNHALC
  mouse

 
S5 ___MKGCSSYLMYSF
S6 __MKGCSSYLMYSFG
Y7 _MKGCSSYLMYSFGG
Y10 GCSSYLMYSFGGLLS
S17 YSFGGLLSLWILLVS
T30 VSSTNQCTVRYNVAD
T73 RLPPTNFTRYSQLAI
S87‑p ILDAGFNsISKLEPE
S206 SLRKLDLSSNPLKEF
S207 LRKLDLSSNPLKEFS
S351 HPNIDDFSFQWLKYL
Y384 TGLVSLKYLSLSKTF
T392 LSLSKTFTSLQTLTN
S393 SLSKTFTSLQTLTNE
Y760‑p EQFEYTAyIIHAHKD
T819 RKIIFVITHHLLKDP
Y859 FLQNIPDYKLNHALC
  rat

 
S5‑p ___MKGRssyLIySF
S6‑p __MKGRssyLIySFG
Y7‑p _MKGRssyLIySFGG
Y10‑p GRssyLIySFGGLLs
S17‑p ySFGGLLsLWILVVS
T30‑p VSSTNQCtVRYNVAD
T73 GLPPANFTRYSQLAL
S87 LLDAGFNSISKLEPE
S206 SLQKLDLSSNPLKEF
S207 LQKLDLSSNPLKEFS
S351 HPNIDDFSFQWLKCL
Y384 TGLVSLKYLSLSKTF
T392 LSLSKTFTGLQTLTN
G393 SLSKTFTGLQTLTNE
Y760‑p EQFEYTAyIIHAQKD
T819 RKIIFVITHHLLKDP
Y859 FLQNIPDYKLNHALC
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