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Protein Page:
WWOX (human)

WWOX an enzyme which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). Expressed at high levels in hormonally regulated tissues such as testis, ovary, and prostate. Its SRD domain suggest a role for this gene in steroid metabolism. Shown to be an essential mediator of tumor necrosis factor-alpha-induced apoptosis in the mouse. May play a similar role in the human. May function as a suppressor of tumor growth. Alternative splicing of this gene generates 7 isoforms. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC 1.1.1.-; Oxidoreductase; Tumor suppressor
Chromosomal Location of Human Ortholog: 16q23
Cellular Component: cytoplasm; cytosol; Golgi apparatus; microvillus; mitochondrion; nucleus; plasma membrane
Molecular Function: coenzyme binding; cofactor binding; enzyme binding; oxidoreductase activity; protein binding; protein dimerization activity
Biological Process: negative regulation of Wnt receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; skeletal morphogenesis; steroid metabolic process
Disease: Epileptic Encephalopathy, Early Infantile, 28; Spinocerebellar Ataxia, Autosomal Recessive 12
Reference #:  Q9NZC7 (UniProtKB)
Alt. Names/Synonyms: D16S432E; FOR; FRA16D; Fragile site FRA16D oxidoreductase; HHCMA56; PRO0128; SDR41C1; short chain dehydrogenase/reductase family 41C, member 1; WOX1; WW domain containing oxidoreductase; WW domain-containing oxidoreductase; WW domain-containing protein WWOX; WWOX
Gene Symbols: WWOX
Molecular weight: 46,677 Da
Basal Isoelectric point: 6.71  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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