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Protein Page:
TACE (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TACE a type I membrane protein with disintegrin and metalloprotease activity. An ubiquitously expressed ectoenzyme of peptidase family M12B. Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the this activity. Possesses a narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha) to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, and the amyloid precursor protein. Also involved in the activation of Notch pathway. Binds 1 zinc ion per subunit. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.24.86; Membrane protein, integral; Motility/polarity/chemotaxis; Protease
Chromosomal Location of Human Ortholog: 2p25
Cellular Component: actin cytoskeleton; apical plasma membrane; cell surface; cytoplasm; focal adhesion; integral to plasma membrane; intercellular junction; lipid raft; membrane; plasma membrane
Molecular Function: integrin binding; interleukin-6 receptor binding; metalloendopeptidase activity; metallopeptidase activity; Notch binding; PDZ domain binding; protein binding; SH3 domain binding; zinc ion binding
Biological Process: B cell differentiation; cell adhesion; cell adhesion mediated by integrin; cell motility involved in cell locomotion; defense response to Gram-positive bacterium; epidermal growth factor receptor signaling pathway; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; germinal center formation; membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; negative regulation of transforming growth factor beta receptor signaling pathway; neutrophil mediated immunity; Notch receptor processing; Notch signaling pathway; PMA-inducible membrane protein ectodomain proteolysis; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell motility; positive regulation of cell proliferation; positive regulation of chemokine production; positive regulation of epidermal growth factor receptor activity; positive regulation of leukocyte chemotaxis; positive regulation of protein amino acid phosphorylation; positive regulation of transforming growth factor beta receptor signaling pathway; proteolysis; regulation of mast cell apoptosis; response to drug; response to high density lipoprotein stimulus; response to hypoxia; response to lipopolysaccharide; spleen development; T cell differentiation in the thymus; tumor necrosis factor-mediated signaling pathway; wound healing, spreading of epidermal cells
Disease: Inflammatory Skin And Bowel Disease, Neonatal, 1
Reference #:  P78536 (UniProtKB)
Gene Symbols: ADAM17
Molecular weight: 93,021 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  ErbB/HER Signaling  |  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TACE

Protein Structure Not Found.
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Sites Implicated In
cell cycle regulation: T735‑p
enzymatic activity, induced: T735‑p, S819‑p
intracellular localization: T735‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 F26 RPPDDPGFGPHQRLE
0 1 P28 PDDPGFGPHQRLEKL
0 1 Y82‑p LKRHFKLyLTSSTER
0 1 K168‑ub DKRMLVYkSEDIKNV
0 1 K182‑ub VSRLQSPkVCGYLKV
0 1 K302‑ub EKHYNMAkSYPNEEK
0 1 Y379‑p PVGKKNIyLNsGLTS
0 1 S382‑p KKNIyLNsGLTSTKN
0 1 Y433‑p NEDQGGKyVMyPIAV
0 1 Y436‑p QGGKyVMyPIAVSGD
2 0 Y702 DKKLDKQYESLsLFH
0 1 S706‑p DKQYESLsLFHPSNV
0 4 K728‑ub SASVRIIkPFPAPQt
12 14 T735‑p kPFPAPQtPGRLQPA
0 11 T761‑p LDHQRMDtIQEDPst
0 4 S767‑p DtIQEDPstDsHMDE
0 4 T768‑p tIQEDPstDsHMDED
0 6 S770‑p QEDPstDsHMDEDGF
0 1 K779‑ub MDEDGFEkDPFPNsS
0 2 S785‑p EkDPFPNsSTAAksF
0 1 K790‑ub PNsSTAAksFEDLtD
3 42 S791‑p NsSTAAksFEDLtDH
0 1 T796‑p AksFEDLtDHPVTRS
2 2 S808 TRSEKAASFKLQRQN
3 6 S819‑p QRQNRVDsKETEC__
  mouse

 
S26‑p RPPEEAGsGsHPRLE
S28‑p PEEAGsGsHPRLEKL
Y82 LKRHFKLYLTSSTER
K168 DKRMLVYKSEDIKDF
K182 FSRLQSPKVCGYLNA
K302 ERHFNMAKSFPNEEK
Y379 PTVKKNIYLNSGLTS
S382 KKNIYLNSGLTSTKN
Y433 NEDQGGKYVMYPIAV
Y436 QGGKYVMYPIAVSGD
Y702 DKKLDKQYESLSLFH
S706 DKQYESLSLFHHSNI
K728‑ub SASVRIIkPFPAPQt
T735‑p kPFPAPQtPGRLQAL
T764‑p LDHQRMDtIQEDPst
S770‑p DtIQEDPstDsHADD
T771‑p tIQEDPstDsHADDD
S773‑p QEDPstDsHADDDGF
K782 ADDDGFEKDPFPNsS
S788‑p EKDPFPNsSTAAKsF
K793 PNsSTAAKsFEDLTD
S794‑p NsSTAAKsFEDLTDH
T799 AKsFEDLTDHPVTRS
S811‑p TRSEKAAsFKLQRQS
S822‑p QRQSRVDsKETEC__
  rat

 
S26 RPPEEPGSGSHLRLE
S28 PEEPGSGSHLRLEKL
Y82 LKRHFKLYLTSSTER
K168 DKRMLVYKSEDIKDF
K182 FSRLQSPKVCGYLNA
K302 ERHFNMAKSFPNEEK
Y379 PGVKKNIYLNSGLTS
S382 KKNIYLNSGLTSTKN
Y433 NEDQGGKYVMYPIAV
Y436 QGGKYVMYPIAVSGD
Y702‑p DKKLDKQyESLSLFH
S706 DKQyESLSLFHHSNI
K728 SASVRIIKPFPAPQt
T735‑p KPFPAPQtPGRLQAL
T764 LDHQRMDTIQEDPst
S770‑p DTIQEDPstDsHVDD
T771‑p TIQEDPstDsHVDDD
S773‑p QEDPstDsHVDDDGF
K782 VDDDGFEKDPFPNSS
S788 EKDPFPNSSAAAKsF
K793 PNSSAAAKsFEDLTD
S794‑p NSSAAAKsFEDLTDH
T799 AKsFEDLTDHPVTRS
S811‑p TRSEKAAsFKLQRQS
S822 QRQSRVDSKETEC__
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