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Protein Page:
TACE (human)

Overview
TACE a type I membrane protein with disintegrin and metalloprotease activity. An ubiquitously expressed ectoenzyme of peptidase family M12B. Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the this activity. Possesses a narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha) to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, and the amyloid precursor protein. Also involved in the activation of Notch pathway. Binds 1 zinc ion per subunit. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.24.86; Membrane protein, integral; Motility/polarity/chemotaxis; Protease
Chromosomal Location of Human Ortholog: 2p25
Cellular Component: actin cytoskeleton; apical plasma membrane; cell surface; cytoplasm; focal adhesion; integral to plasma membrane; intercellular junction; lipid raft; membrane; plasma membrane
Molecular Function: integrin binding; interleukin-6 receptor binding; metalloendopeptidase activity; metallopeptidase activity; Notch binding; PDZ domain binding; protein binding
Biological Process: B cell differentiation; cell adhesion; cell adhesion mediated by integrin; cell motility involved in cell locomotion; defense response to Gram-positive bacterium; epidermal growth factor receptor signaling pathway; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; germinal center formation; membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; negative regulation of transforming growth factor beta receptor signaling pathway; neutrophil mediated immunity; Notch receptor processing; PMA-inducible membrane protein ectodomain proteolysis; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell motility; positive regulation of cell proliferation; positive regulation of chemokine production; positive regulation of epidermal growth factor receptor activity; positive regulation of leukocyte chemotaxis; positive regulation of protein amino acid phosphorylation; positive regulation of transforming growth factor beta receptor signaling pathway; proteolysis; regulation of mast cell apoptosis; response to drug; response to high density lipoprotein stimulus; response to hypoxia; response to lipopolysaccharide; spleen development; T cell differentiation in the thymus; tumor necrosis factor-mediated signaling pathway; wound healing, spreading of epidermal cells
Disease: Inflammatory Skin And Bowel Disease, Neonatal, 1
Reference #:  P78536 (UniProtKB)
Alt. Names/Synonyms: ADA17; ADAM 17; ADAM metallopeptidase domain 17; ADAM metallopeptidase domain 18; ADAM17; ADAM18; CD156B; CSVP; Disintegrin and metalloproteinase domain-containing protein 17; MGC71942; Snake venom-like protease; TACE; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme; tumor necrosis factor, alpha, converting enzyme
Gene Symbols: ADAM17
Molecular weight: 93,021 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  ErbB/HER Signaling  |  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TACE

Protein Structure Not Found.
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