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Protein Page:
ATG3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ATG3 an E2-like enzyme essential for Apg8p lipidation. Note: This description may include information from UniProtKB.
Protein type: Enzyme, cellular metabolism; EC 6.3.2.-; Ubiquitin conjugating system; Autophagy
Chromosomal Location of Human Ortholog: 3q13.2
Cellular Component: cytoplasmic ubiquitin ligase complex; cytosol
Molecular Function: APG12 conjugating enzyme activity; APG8 conjugating enzyme activity; enzyme binding; ligase activity; protein binding; small conjugating protein ligase activity
Biological Process: autophagic vacuole formation; macroautophagy; mitochondrial fragmentation during apoptosis; mitochondrion degradation; protein modification process; protein targeting to membrane; protein ubiquitination
Reference #:  Q9NT62 (UniProtKB)
Alt. Names/Synonyms: 2610016C12Rik; APG3; APG3 autophagy 3-like; APG3-like; APG3L; ATG3; ATG3 autophagy related 3 homolog (S. cerevisiae); autophagy Apg3p/Aut1p-like; Autophagy-related protein 3; DKFZp564M1178; FLJ22125; hApg3; MGC15201; PC3-96; Protein PC3-96
Gene Symbols: ATG3
Molecular weight: 35,864 Da
Basal Isoelectric point: 4.66  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ATG3

Protein Structure Not Found.
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Download ChimeraX Script


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 K11‑ub VINTVKGkALEVAEy
0 322 Y18‑p kALEVAEyLtPVLKE
0 7 T20‑p LEVAEyLtPVLKESK
0 1 K24 EyLtPVLKESKFKET
0 1 K71‑ub KAYLPTGkQFLVTKN
0 1 D104‑ca IIEEDDGdGGWVDTy
0 5 Y111‑p dGGWVDTyHNTGItG
0 2 T117‑p TyHNTGItGITEAVK
0 2 K131‑ub KEITLENkDNIRLQD
0 1 N133 ITLENkDNIRLQDCS
0 4 K185‑ub IVEACKAktDAGGED
0 1 T186‑p VEACKAktDAGGEDA
0 1 K208 DLYITYDKYYQTPRL
0 5 K208‑ub DLYITYDkYYQTPRL
0 1 K243‑ub ISQDHVKkTVTIENH
0 1 T244 SQDHVKkTVTIENHP
0 1 T246 DHVKkTVTIENHPHL
0 1 T313‑p YDYTRHFtM______
  ATG3 iso2  
K11 VINTVKGKALEVAEY
Y18 KALEVAEYLTPVLKE
T20 LEVAEYLTPVLKESK
K24 EYLTPVLKESKFKET
K71 KAYLPTGKQFLVTKN
D104 IIEEDDGDGGWVDTY
Y111 DGGWVDTYHNTGITG
T117 TYHNTGITGITEAVK
K131 KEITLENKDNIRLQD
N133 ITLENKDNIRLQDCS
K185 IVEACKAKTDAGGED
T186 VEACKAKTDAGGEDA
K208 DLYITYDKYYQTPRL
K208 DLYITYDKYYQTPRL
K243 ISQDHVKKTVTIENH
T244 SQDHVKKTVTIENHP
T246 DHVKKTVTIENHPHL
- gap
  mouse

 
K11‑ub VINTVKGkALEVAEy
Y18‑p kALEVAEyLTPVLkE
T20 LEVAEyLTPVLkESK
K24‑ub EyLTPVLkESKFKET
K71 KAYLPTDKQFLVTKN
D104 IIEEDDGDGGWVDTY
Y111 DGGWVDTYHNTGITG
T117 TYHNTGITGITEAVK
K131‑ub KEITLESkDsIKLQD
S133‑p ITLESkDsIKLQDCS
K185 IVEACKAKADAGGED
A186 VEACKAKADAGGEDA
K208‑ac DLYITYDkYYQTPRL
K208‑ub DLYITYDkYYQTPRL
K243 ISQDHVKKtVtIENH
T244‑p SQDHVKKtVtIENHP
T246‑p DHVKKtVtIENHPHL
T313 YDYTRHFTM______
  rat

 
K11 VINTVKGKALEVAEY
Y18 KALEVAEYLTPVLKE
T20 LEVAEYLTPVLKESK
K24 EYLTPVLKESKFKET
K71 KAYLPTGKQFLVTKN
D104 IIEEDDGDGGWVDTY
Y111 DGGWVDTYHNTGITG
T117 TYHNTGITGITEAVK
K131 KEITLESKDSIKLQD
S133 ITLESKDSIKLQDCS
K185 IVEACKAKADAGGED
A186 VEACKAKADAGGEDA
K208 DLYITYDKYYQTPRL
K208 DLYITYDKYYQTPRL
K243 ISQDHVKKTVTIENH
T244 SQDHVKKTVTIENHP
T246 DHVKKTVTIENHPHL
T313 YDYTRHFTM______
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