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Protein Page:
GLI2 (human)

GLI2 Acts as a transcriptional activator. May play a role during embryogenesis. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the TRE-2S regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1. Implicated in the transduction of SHH signal. Interaction with ZIC. Belongs to the GLI C2H2-type zinc-finger protein family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 2q14.2
Cellular Component: cilium; cytosol; nucleolus; nucleoplasm; nucleus
Molecular Function: protein binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding; zinc ion binding
Biological Process: axon guidance; branching morphogenesis of a tube; cell proliferation; cerebellar cortex morphogenesis; developmental growth; embryonic gut development; floor plate formation; heart development; hindbrain development; hindgut morphogenesis; kidney development; lung development; mammary gland development; negative regulation of transcription from RNA polymerase II promoter; neuron development; odontogenesis of dentine-containing teeth; osteoblast development; pattern specification process; pituitary gland development; positive regulation of DNA replication; positive regulation of T cell differentiation in the thymus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; proximal/distal pattern formation; skeletal development; smoothened signaling pathway; smoothened signaling pathway involved in ventral spinal cord interneuron specification; spinal cord dorsal/ventral patterning; spinal cord ventral commissure morphogenesis; tube development; ventral midline development; ventral spinal cord development
Reference #:  P10070 (UniProtKB)
Alt. Names/Synonyms: GLI family zinc finger 2; GLI-Kruppel family member GLI2; GLI2; glioma-associated oncogene family zinc finger 2; HPE9; oncogene GLI2; Tax helper protein; tax helper protein 1; tax helper protein 2; tax-responsive element-2 holding protein; tax-responsive element-25-bp sequence binding protein; THP; THP1; THP2; Zinc finger protein GLI2
Gene Symbols: GLI2
Molecular weight: 167,783 Da
Basal Isoelectric point: 6.9  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling
Select Structure to View Below


Protein Structure Not Found.

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