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Protein Page:
DBN1 (human)

DBN1 a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. Expressed in brain neurons, heart, placenta, skeletal muscle, kidney and pancreas. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component: actin cytoskeleton; cell-cell adherens junction; growth cone; plasma membrane
Molecular Function: profilin binding; protein binding
Biological Process: actin filament organization
Reference #:  Q16643 (UniProtKB)
Alt. Names/Synonyms: D0S117E; DBN1; Developmentally-regulated brain protein; DKFZp434D064; DREB; Drebrin; drebrin 1; drebrin E; drebrin E2; drebrin-1
Gene Symbols: DBN1
Molecular weight: 71,429 Da
Basal Isoelectric point: 4.41  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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