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Protein Page:
BDP1 (human)

Overview
BDP1 a member of the non-receptor protein tyrosine phosphatase (PTP) family. Contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This gene was found to be expressed in brain, colon tissues, and several different tumor-derived cell lines. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2q21.1
Molecular Function: protein binding
Biological Process: protein amino acid dephosphorylation
Reference #:  Q99952 (UniProtKB)
Alt. Names/Synonyms: BDP1; Brain-derived phosphatase; protein tyrosine phosphatase, non-receptor type 18 (brain-derived); PTN18; PTP-HSCF; PTPN18; Tyrosine-protein phosphatase non-receptor type 18
Gene Symbols: PTPN18
Molecular weight: 50,482 Da
Basal Isoelectric point: 8.57  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BDP1

Protein Structure Not Found.
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Sites Implicated In
molecular association, regulation: Y281‑p, Y303‑p, Y354‑p, Y389‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S10‑p RSLDSARsFLERLEA
0 1 S76‑p DQTRVILsLLQEEGH
1 0 Y281‑p AVQTEEQyRFLYHTV
1 0 Y303‑p LQNASPHyQNIKENC
0 13 Y314‑p KENCAPLyDDALFLR
0 1 T322‑p DDALFLRtPQALLAI
0 4 S341‑p GGVLRSIsVPGsPGH
0 3 S345‑p RSIsVPGsPGHAMAD
1 0 Y354‑p GHAMADTyAVVQKRG
0 1 T370‑p PAGAGSGtQTGtGtG
0 1 T374‑p GSGtQTGtGtGTGAR
0 1 T376‑p GtQTGtGtGTGARsA
0 1 S382‑p GtGTGARsAEEAPLy
1 665 Y389‑p sAEEAPLysKVtPRA
0 2 S390‑p AEEAPLysKVtPRAQ
0 9 T393‑p APLysKVtPRAQRPG
0 4 S419‑p GRVPADQsPAGsGAy
0 1 S423‑p ADQsPAGsGAyEDVA
0 10 Y426‑p sPAGsGAyEDVAGGA
0 1 T435‑p DVAGGAQtGGLGFNL
0 1 T458‑p RDPPAEWtRV_____
  mouse

 
S10 RHTDLVRSFLEQLEA
S76 DETRVILSLLQEEGH
Y281 AVQTEEQYRFLYHTV
Y303 LQDTSPHYQNLKENC
C314 KENCAPICKEAFSLR
T322 KEAFSLRTSSALPAT
S341 GGVLRSISVPAPPTL
P345 RSISVPAPPTLPMAD
Y354 TLPMADTYAVVQKRG
P370 SAGTGPGPRAPTSTD
T374 GPGPRAPTSTDTPIy
T376 GPRAPTSTDTPIysQ
- gap
Y381‑p TSTDTPIysQVAPRA
S382‑p STDTPIysQVAPRAQ
A385 TPIysQVAPRAQRPV
N412 RRVPADQNSSGPDAY
P416 ADQNSSGPDAYEEVT
Y419 NSSGPDAYEEVTDGA
T428 EVTDGAQTGGLGFNL
T451 RDPPAEWTRV_____
  rat

 
S10 RQSDLVRSFLEQQEA
S76 DETRVILSLLQEEGH
Y281‑p AVQTEEQyRFLYHTV
Y303 LQNNSPLYQNLKENR
C314 KENRAPICKDSSSLR
T322 KDSSSLRTSSALPAT
S341 GGVLRSISVPGPPTL
P345 RSISVPGPPTLPMAD
Y354 TLPMADTYAVVQKRG
T370 SGSTGPGTRAPNSTD
N374 GPGTRAPNSTDTPIY
T376 GTRAPNSTDTPIYSQ
- gap
Y381 NSTDTPIYSQVAPRI
S382 STDTPIYSQVAPRIQ
A385 TPIYSQVAPRIQRPV
N412 GRVPADENPSGPDAY
P416 ADENPSGPDAYEEVT
Y419 NPSGPDAYEEVTDGA
T428 EVTDGAQTGGLGFNL
T451 RDPPAEWTRV_____
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