Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
ARHGAP5 (human)

ARHGAP5 a GTPase activating protein for Rho family members. May play a role in the reduction of the p21rasGTPase-activating potential of p120GAP. Negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Note: This description may include information from UniProtKB.
Protein type: GAPs; GAPs, Rac/Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 14q12
Cellular Component: cytoplasm; cytosol; endoplasmic reticulum
Molecular Function: GTPase activator activity; GTPase activity; protein binding; SH2 domain binding
Biological Process: cell adhesion; regulation of small GTPase mediated signal transduction; Rho protein signal transduction
Reference #:  Q13017 (UniProtKB)
Alt. Names/Synonyms: ARHGAP5; GFI2; growth factor independent 2; p100 RasGAP-associated p105 protein; p105 RhoGAP; p190-B; p190BRhoGAP; RHG05; Rho GTPase activating protein 5; Rho GTPase-activating protein 5; Rho-type GTPase-activating protein 5; RHOGAP5
Gene Symbols: ARHGAP5
Molecular weight: 172,460 Da
Basal Isoelectric point: 6.18  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein