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Protein Page:
GIT1 (human)

GIT1 a multidomain, adaptor protein that regulates cellular processes, such as migration and protrusive activity, by bringing together various signaling molecules, including PIX, PAK, and paxillin. Phosphorylation on Ser-709 increases its binding to paxillin and regulates cellular protrusions. Possesses ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. Functions as part of a multi-molecular signaling complex that regulates membrane protrusions and cell migration. Regulates PLC-gamma activation by c-Src and integrates signal transduction by G protein coupled receptors (GPCR)s and tyrosine kinase receptors (TKRs). Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, ARF; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: cytosol; focal adhesion; membrane
Molecular Function: protein binding
Biological Process: ephrin receptor signaling pathway; regulation of cytokinesis; regulation of G-protein coupled receptor protein signaling pathway
Reference #:  Q9Y2X7 (UniProtKB)
Alt. Names/Synonyms: ARF GAP GIT1; ARF GTPase-activating protein GIT1; CAT-1; CAT1; Cool-associated and tyrosine-phosphorylated protein 1; G protein-coupled receptor kinase interacting ArfGAP 1; G protein-coupled receptor kinase interactor 1; G protein-coupled receptor kinase-interactor 1; GIT1; GRK-interacting protein 1
Gene Symbols: GIT1
Molecular weight: 84,341 Da
Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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