an ATPase enzyme present in all eukaryotes and archaebacteria that functions involved in vesicle transport and fusion, and 26S proteasomal degradation. Functions to extract protein molecules from large protein assemblies, membranes and chromatin, facilitating the proteasomal degradation of the extracted proteins by the proteasome. Involved in: the fragmentation of Golgi stacks during mitosis, and for their reassembly after mitosis; the formation of the transitional endoplasmic reticulum (tER); spindle disassembly at the end of mitosis; and the formation of a closed nuclear envelope. Involved in endoplasmic reticulum stress-induced preemptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. Regulates NFKappaB pathway, which is important for metastasis of osteosarcoma. Acts as a negative regulator of type I interferon production by interacting with DDX58: interaction takes place when DDX58 is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of DDX58. Tyrosine phosphorylation regulates its cell cycle-dependent nuclear localization. Note: This description may include information from UniProtKB.
Protein type: Chaperone; DNA repair, damage; EC 18.104.22.168; Endoplasmic reticulum; Hydrolase
Molecular Function: ATPase activity; identical protein binding; polyubiquitin binding; protein binding; protein domain specific binding; protein phosphatase binding; ubiquitin protein ligase binding
Biological Process: autophagy; bypass DNA synthesis; caspase activation; double-strand break repair; ER-associated protein catabolic process; establishment of protein localization; NADH metabolic process; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein catabolic process; positive regulation of protein complex assembly; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid N-linked glycosylation via asparagine; protein ubiquitination; regulation of apoptosis; response to DNA damage stimulus; retrograde protein transport, ER to cytosol; unfolded protein response; viral genome replication