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Protein Page:
VCP (human)

VCP valosin-containing protein (VCP) is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. VCP, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope and of the transitional endoplasmic reticulum (tER). Regulates NFKappaB pathway, which is important for metastasis of osteosarcoma. Tyrosine phosphorylation regulates its cell cycle-dependent nuclear localization. Note: This description may include information from UniProtKB.
Protein type: Chaperone; DNA repair, damage; EC; Endoplasmic reticulum; Hydrolase
Chromosomal Location of Human Ortholog: 9p13.3
Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; intracellular membrane-bound organelle; lipid particle; nucleoplasm; nucleus; perinuclear region of cytoplasm; proteasome complex
Molecular Function: ATPase activity; identical protein binding; polyubiquitin binding; protein binding; protein domain specific binding; protein phosphatase binding; ubiquitin protein ligase binding
Biological Process: autophagy; bypass DNA synthesis; caspase activation; double-strand break repair; ER-associated protein catabolic process; establishment of protein localization; NADH metabolic process; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein catabolic process; positive regulation of protein complex assembly; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid N-linked glycosylation via asparagine; protein ubiquitination; regulation of apoptosis; response to DNA damage stimulus; retrograde protein transport, ER to cytosol; unfolded protein response; viral genome replication
Disease: Amyotrophic Lateral Sclerosis 14, With Or Without Frontotemporal Dementia; Charcot-marie-tooth Disease, Axonal, Type 2y; Inclusion Body Myopathy With Early-onset Paget Disease With Or Without Frontotemporal Dementia 1
Reference #:  P55072 (UniProtKB)
Alt. Names/Synonyms: 15S Mg(2+)-ATPase p97 subunit; IBMPFD; MGC131997; MGC148092; MGC8560; p97; TER ATPase; TERA; Transitional endoplasmic reticulum ATPase; Valosin-containing protein; VCP; yeast Cdc48p homolog
Gene Symbols: VCP
Molecular weight: 89,322 Da
Basal Isoelectric point: 5.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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