valosin-containing protein (VCP) is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. VCP, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope and of the transitional endoplasmic reticulum (tER). Regulates NFKappaB pathway, which is important for metastasis of osteosarcoma. Tyrosine phosphorylation regulates its cell cycle-dependent nuclear localization. Note: This description may include information from UniProtKB.
Protein type: Chaperone; DNA repair, damage; EC 220.127.116.11; Endoplasmic reticulum; Hydrolase
Molecular Function: ATPase activity; identical protein binding; polyubiquitin binding; protein binding; protein domain specific binding; protein phosphatase binding; ubiquitin protein ligase binding
Biological Process: autophagy; bypass DNA synthesis; caspase activation; double-strand break repair; ER-associated protein catabolic process; establishment of protein localization; NADH metabolic process; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein catabolic process; positive regulation of protein complex assembly; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid N-linked glycosylation via asparagine; protein ubiquitination; regulation of apoptosis; response to DNA damage stimulus; retrograde protein transport, ER to cytosol; unfolded protein response; viral genome replication