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Protein Page:
NCK1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NCK1 adapter protein containing Src homology 2 and 3 (SH2 and SH3) domains. Transduces signals from tyrosine-phosphorylated growth factor receptors to their cellular substrates. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 3q21
Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; plasma membrane; protein phosphatase type 1 complex; ribosome; trans-Golgi network
Molecular Function: ARF guanyl-nucleotide exchange factor activity; protein binding; protein binding, bridging; protein kinase inhibitor activity; receptor binding; receptor tyrosine kinase binding
Biological Process: negative regulation of peptidyl-serine phosphorylation; positive regulation of actin filament polymerization; positive regulation of T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; T cell activation; T cell receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; vesicle-mediated transport
Reference #:  P16333 (UniProtKB)
Alt. Names/Synonyms: Cytoplasmic protein NCK1; melanoma NCK protein; MGC12668; NCK; NCK adaptor protein 1; NCK tyrosine kinase; Nck-1; NCK1; NCKalpha; non-catalytic region of tyrosine kinase; SH2/SH3 adaptor protein NCK-alpha
Gene Symbols: NCK1
Molecular weight: 42,864 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  ErbB/HER Signaling  |  Insulin Receptor Signaling  |  T Cell Receptor Signaling  |  Translation: eIF2  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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NCK1

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 Y13‑p VVVAKFDyVAQQEQE
0 5 S61‑p NYVERKNsARKAsIV
0 7 S66‑p KNsARKAsIVKNLKD
0 4 T74‑p IVKNLKDtLGIGKVK
0 413 S85‑p GKVKRKPsVPdsAsP
0 2 D88‑ca KRKPsVPdsAsPADD
0 39 S89‑p RKPsVPdsAsPADDs
0 25 S91‑p PsVPdsAsPADDsFV
0 66 S96‑p sAsPADDsFVDPGER
2 877 Y105‑p VDPGERLyDLNMPAy
0 111 Y112‑p yDLNMPAyVKFNYMA
0 1 S147 SDGWWRGSYNGQVGW
0 1 Y148 DGWWRGSYNGQVGWF
0 1 Y159 VGWFPSNYVTEEGDs
0 1 T161 WFPSNYVTEEGDsPL
0 16 S166‑p YVTEEGDsPLGDHVG
1 0 K178‑ub HVGSLSEkLAAVVNN
0 3 S262‑p LTSGLEPsPPQCDyI
0 14 Y268‑p PsPPQCDyIRPSLTG
0 2 S313‑p LIRDSESsPNDFSVS
0 18 Y339‑p VQLKETVyCIGQRKF
0 3 S347‑p CIGQRKFsTMEELVE
0 2 T348 IGQRKFsTMEELVEH
0 1 Y356 MEELVEHYKKAPIFT
0 2 Y371 SEQGEKLYLVKHLS_
  NCK1 iso2  
- gap
- gap
- gap
- gap
S21‑p GKVKRKPsVPDSAsP
D24 KRKPsVPDSAsPADD
S25 RKPsVPDSAsPADDS
S27‑p PsVPDSAsPADDSFV
S32 SAsPADDSFVDPGER
Y41 VDPGERLYDLNMPAY
Y48 YDLNMPAYVKFNYMA
S83 SDGWWRGSYNGQVGW
Y84 DGWWRGSYNGQVGWF
Y95 VGWFPSNYVTEEGDS
T97 WFPSNYVTEEGDSPL
S102 YVTEEGDSPLGDHVG
K114 HVGSLSEKLAAVVNN
S198 LTSGLEPSPPQCDYI
Y204 PSPPQCDYIRPSLTG
S249 LIRDSESSPNDFSVS
Y275 VQLKETVYCIGQRKF
S283 CIGQRKFSTMEELVE
T284 IGQRKFSTMEELVEH
Y292 MEELVEHYKKAPIFT
Y307 SEQGEKLYLVKHLS_
  mouse

 
Y13 VVVAKFDYVAQQEQE
S61 NYVERKNSARKAsIV
S66‑p KNSARKAsIVKNLKD
T74‑p IVKNLKDtLGIGKVK
S85‑p GKVKRKPsVPDtAsP
D88 KRKPsVPDtAsPADD
T89‑p RKPsVPDtAsPADDs
S91‑p PsVPDtAsPADDsFV
S96‑p tAsPADDsFVDPGER
Y105‑p VDPGERLyDLNMPAF
F112 yDLNMPAFVKFNYMA
S147‑p SDGWWRGsyNGQIGW
Y148‑p DGWWRGsyNGQIGWF
Y159‑p IGWFPSNyVtEEGDs
T161‑p WFPSNyVtEEGDsPL
S166‑p yVtEEGDsPLGDHVG
K178 HVGSLSEKLAAVVNN
S262 LTSGLEPSPPQCDyI
Y268‑p PSPPQCDyIRPSLTG
S313 LIRDSESSPNDFSVS
Y339 VQLKETVYCIGQRKF
S347‑p CIGQRKFstMEELVE
T348‑p IGQRKFstMEELVEH
Y356 MEELVEHYKKAPIFT
Y371‑p SEQGEKLyLVKHLS_
  rat

 
Y13 VVVAKFDYVAQQEQE
S61 NYVERKNSARKAsIV
S66‑p KNSARKAsIVKNLKD
T74 IVKNLKDTLGIGKVK
S85‑p GKVKRKPsVPDTAsP
D88 KRKPsVPDTAsPADD
T89 RKPsVPDTAsPADDS
S91‑p PsVPDTAsPADDSFV
S96 TAsPADDSFVDPGER
Y105‑p VDPGERLyDLNMPAF
F112 yDLNMPAFVKFNYMA
S147 SDGWWRGSYNGQIGW
Y148 DGWWRGSYNGQIGWF
Y159 IGWFPSNYVTEEGDs
T161 WFPSNYVTEEGDsPL
S166‑p YVTEEGDsPLGDHVG
K178 HVGSLSEKLAAVVNN
S262 LTSGLEPSPPQCDYI
Y268 PSPPQCDYIRPSLTG
S313 LIRDSESSPNDFSVS
Y339 VQLKETVYCIGQRKF
S347‑p CIGQRKFsTMEELVE
T348 IGQRKFsTMEELVEH
Y356‑p MEELVEHyKKAPIFT
Y371 SEQGEKLYLVKHLS_
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