adapter protein containing Src homology 2 and 3 (SH2 and SH3) domains. Transduces signals from tyrosine-phosphorylated growth factor receptors to their cellular substrates. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Molecular Function: ARF guanyl-nucleotide exchange factor activity; cytoskeletal adaptor activity; protein binding; protein binding, bridging; protein domain specific binding; protein kinase inhibitor activity; receptor binding; receptor signaling complex scaffold activity; receptor tyrosine kinase binding; SH3/SH2 adaptor activity
Biological Process: actin filament organization; lamellipodium biogenesis; negative regulation of peptidyl-serine phosphorylation; negative regulation of protein kinase activity; positive regulation of actin filament polymerization; positive regulation of GTPase activity; positive regulation of T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; response to other organism; signal complex assembly; substrate-bound cell migration, cell extension; T cell activation; T cell receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; vesicle-mediated transport
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.