Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
NCK1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NCK1 adapter protein containing Src homology 2 and 3 (SH2 and SH3) domains. Transduces signals from tyrosine-phosphorylated growth factor receptors to their cellular substrates. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3q21
Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; intercellular junction; nucleus; plasma membrane; protein phosphatase type 1 complex; ribosome; trans-Golgi network; vesicle membrane
Molecular Function: ARF guanyl-nucleotide exchange factor activity; cytoskeletal adaptor activity; protein binding; protein binding, bridging; protein domain specific binding; protein kinase inhibitor activity; receptor binding; receptor signaling complex scaffold activity; receptor tyrosine kinase binding; SH3/SH2 adaptor activity
Biological Process: actin filament organization; lamellipodium biogenesis; negative regulation of peptidyl-serine phosphorylation; negative regulation of protein kinase activity; positive regulation of actin filament polymerization; positive regulation of GTPase activity; positive regulation of T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; response to other organism; signal complex assembly; substrate-bound cell migration, cell extension; T cell activation; T cell receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; vesicle-mediated transport
Reference #:  P16333 (UniProtKB)
Gene Symbols: NCK1
Molecular weight: 42,864 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  ErbB/HER Signaling  |  Insulin Receptor Signaling  |  T Cell Receptor Signaling  |  Translation: eIF2  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NCK1

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 Y13‑p VVVAKFDyVAQQEQE
0 5 S61‑p NYVERKNsARKAsIV
0 8 S66‑p KNsARKAsIVKNLKD
0 5 T74‑p IVKNLKDtLGIGKVK
0 413 S85‑p GKVKRKPsVPdsAsP
0 2 D88‑ca KRKPsVPdsAsPADD
0 38 S89‑p RKPsVPdsAsPADDs
0 25 S91‑p PsVPdsAsPADDsFV
0 66 S96‑p sAsPADDsFVDPGER
2 877 Y105‑p VDPGERLyDLNMPAy
0 110 Y112‑p yDLNMPAyVKFNYMA
0 1 S147 SDGWWRGSYNGQVGW
0 1 Y148 DGWWRGSYNGQVGWF
0 1 Y159 VGWFPSNYVTEEGDs
0 1 T161 WFPSNYVTEEGDsPL
0 17 S166‑p YVTEEGDsPLGDHVG
1 0 K178‑ub HVGSLSEkLAAVVNN
0 4 S262‑p LTSGLEPsPPQCDyI
0 14 Y268‑p PsPPQCDyIRPSLTG
0 2 S313‑p LIRDSESsPNDFSVS
0 18 Y339‑p VQLKETVyCIGQRKF
0 4 S347‑p CIGQRKFsTMEELVE
0 2 T348 IGQRKFsTMEELVEH
0 1 Y356 MEELVEHYKKAPIFT
0 2 Y371 SEQGEKLYLVKHLS_
  NCK1 iso2  
- gap
- gap
- gap
- gap
S21‑p GKVKRKPsVPDSAsP
D24 KRKPsVPDSAsPADD
S25 RKPsVPDSAsPADDS
S27‑p PsVPDSAsPADDSFV
S32 SAsPADDSFVDPGER
Y41 VDPGERLYDLNMPAY
Y48 YDLNMPAYVKFNYMA
S83 SDGWWRGSYNGQVGW
Y84 DGWWRGSYNGQVGWF
Y95 VGWFPSNYVTEEGDS
T97 WFPSNYVTEEGDSPL
S102 YVTEEGDSPLGDHVG
K114 HVGSLSEKLAAVVNN
S198 LTSGLEPSPPQCDYI
Y204 PSPPQCDYIRPSLTG
S249 LIRDSESSPNDFSVS
Y275 VQLKETVYCIGQRKF
S283 CIGQRKFSTMEELVE
T284 IGQRKFSTMEELVEH
Y292 MEELVEHYKKAPIFT
Y307 SEQGEKLYLVKHLS_
  mouse

 
Y13 VVVAKFDYVAQQEQE
S61 NYVERKNSARKAsIV
S66‑p KNSARKAsIVKNLKD
T74‑p IVKNLKDtLGIGKVK
S85‑p GKVKRKPsVPDtAsP
D88 KRKPsVPDtAsPADD
T89‑p RKPsVPDtAsPADDs
S91‑p PsVPDtAsPADDsFV
S96‑p tAsPADDsFVDPGER
Y105‑p VDPGERLyDLNMPAF
F112 yDLNMPAFVKFNYMA
S147‑p SDGWWRGsyNGQIGW
Y148‑p DGWWRGsyNGQIGWF
Y159‑p IGWFPSNyVtEEGDs
T161‑p WFPSNyVtEEGDsPL
S166‑p yVtEEGDsPLGDHVG
K178 HVGSLSEKLAAVVNN
S262 LTSGLEPSPPQCDyI
Y268‑p PSPPQCDyIRPSLTG
S313 LIRDSESSPNDFSVS
Y339 VQLKETVYCIGQRKF
S347‑p CIGQRKFstMEELVE
T348‑p IGQRKFstMEELVEH
Y356 MEELVEHYKKAPIFT
Y371‑p SEQGEKLyLVKHLS_
  rat

 
Y13 VVVAKFDYVAQQEQE
S61 NYVERKNSARKAsIV
S66‑p KNSARKAsIVKNLKD
T74 IVKNLKDTLGIGKVK
S85‑p GKVKRKPsVPDTAsP
D88 KRKPsVPDTAsPADD
T89 RKPsVPDTAsPADDS
S91‑p PsVPDTAsPADDSFV
S96 TAsPADDSFVDPGER
Y105‑p VDPGERLyDLNMPAF
F112 yDLNMPAFVKFNYMA
S147 SDGWWRGSYNGQIGW
Y148 DGWWRGSYNGQIGWF
Y159 IGWFPSNYVTEEGDs
T161 WFPSNYVTEEGDsPL
S166‑p YVTEEGDsPLGDHVG
K178 HVGSLSEKLAAVVNN
S262 LTSGLEPSPPQCDYI
Y268 PSPPQCDYIRPSLTG
S313 LIRDSESSPNDFSVS
Y339 VQLKETVYCIGQRKF
S347‑p CIGQRKFsTMEELVE
T348 IGQRKFsTMEELVEH
Y356‑p MEELVEHyKKAPIFT
Y371 SEQGEKLYLVKHLS_
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.