the human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTP-ase activating protein (GAP). May also act as a tumor suppressor. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: GAPs, Rac/Rho; Transcription factor; Motility/polarity/chemotaxis; Tumor suppressor; GAPs
Biological Process: axon guidance; camera-type eye development; forebrain development; negative regulation of Rho protein signal transduction; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of vascular permeability; neural tube closure; positive regulation of GTPase activity; regulation of cell shape; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; transcription, DNA-dependent
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.