the human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTP-ase activating protein (GAP). May also act as a tumor suppressor. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: GAPs; GAPs, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor; Tumor suppressor
Molecular Function: DNA binding; GTPase activator activity; transcription corepressor activity
Biological Process: negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of flagellum biogenesis; regulation of actin polymerization and/or depolymerization; regulation of small GTPase mediated signal transduction