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Protein Page:
4E-BP2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
4E-BP2 eukaryotic translation initiation factor 4E binding protein 2 Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Chromosomal Location of Human Ortholog: 10q21-q22
Cellular Component: cytoplasm
Molecular Function: eukaryotic initiation factor 4E binding; protein binding; translation repressor activity
Biological Process: memory; negative regulation of translational initiation; regulation of synaptic plasticity; regulation of synaptic transmission; social behavior; TOR signaling pathway; translation
Reference #:  Q13542 (UniProtKB)
Alt. Names/Synonyms: 4E-BP2; 4EBP2; eIF4E-binding protein 2; EIF4EBP2; eukaryotic translation initiation factor 4E binding protein 2; Eukaryotic translation initiation factor 4E-binding protein 2; PHASII; phosphorylated, heat and acid stable regulated by insulin protein II
Gene Symbols: EIF4EBP2
Molecular weight: 12,939 Da
Basal Isoelectric point: 6.16  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

4E-BP2

Protein Structure Not Found.
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Sites Implicated In
molecular association, regulation: T37‑p, T46‑p
protein conformation: T37‑p, T46‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S2 ______MSSsAGSGH
0 2 S4‑p ____MSSsAGSGHQP
0 1 S25‑p PTRTVAIsDAAQLPH
0 60 Y34‑p AAQLPHDyCttPGGt
0 18 T36‑p QLPHDyCttPGGtLF
2 69 T37‑p LPHDyCttPGGtLFs
0 11 T41‑p yCttPGGtLFsttPG
0 17 S44‑p tPGGtLFsttPGGtR
0 15 T45‑p PGGtLFsttPGGtRI
2 92 T46‑p GGtLFsttPGGtRII
0 8 T50‑p FsttPGGtRIIyDRK
0 6 Y54‑p PGGtRIIyDRKFLLD
0 1 K57 tRIIyDRKFLLDRRN
0 19 S65‑p FLLDRRNsPMAQtPP
0 22 T70‑p RNsPMAQtPPCHLPN
0 1 S83‑p PNIPGVTsPGTLIED
4923 : Nonphospho-4E-BP1 (Thr46) (87D12) Rabbit mAb
  mouse

 
S2‑p ______MsAsAGGSH
S4‑p ____MsAsAGGSHQP
S25 PTRTVAISDAAQLPQ
Y34‑p AAQLPQDyCttPGGt
T36‑p QLPQDyCttPGGtLF
T37‑p LPQDyCttPGGtLFs
T41‑p yCttPGGtLFsttPG
S44‑p tPGGtLFsttPGGtR
T45‑p PGGtLFsttPGGtRI
T46‑p GGtLFsttPGGtRII
T50‑p FsttPGGtRIIYDRK
Y54 PGGtRIIYDRKFLLD
K57 tRIIYDRKFLLDRRN
S65‑p FLLDRRNsPMAQtPP
T70‑p RNsPMAQtPPCHLPN
S83 PNIPGVTSPGALIED
4923 : Nonphospho-4E-BP1 (Thr46) (87D12) Rabbit mAb
  rat

 
S2 ______MSASAGGGH
S4 ____MSASAGGGHQP
S25 PTRTVAISDAAQLPQ
Y34 AAQLPQDYCTtPGGT
T36 QLPQDYCTtPGGTLF
T37‑p LPQDYCTtPGGTLFs
T41 YCTtPGGTLFsTtPG
S44‑p tPGGTLFsTtPGGTR
T45 PGGTLFsTtPGGTRI
T46‑p GGTLFsTtPGGTRII
T50 FsTtPGGTRIIYDRk
Y54 PGGTRIIYDRkFLLD
K57‑ac TRIIYDRkFLLDRRN
S65 FLLDRRNSPMAQTPP
T70 RNSPMAQTPPCHLPN
S83 PNIPGVTSPGALMED
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