Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
ARRB2 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ARRB2 a member of the arrestin/beta-arrestin protein family. These proteins participate in agonist-mediated desensitization of G-protein-coupled receptors. Acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Expressed at high levels in the CNS and peripheral blood leukocytes. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 17p13
Cellular Component: basolateral plasma membrane; coated pit; cytoplasm; cytoplasmic vesicle; cytosol; dendritic spine; endocytic vesicle; nucleus; plasma membrane; postsynaptic density; postsynaptic membrane
Molecular Function: alpha-1A adrenergic receptor binding; alpha-1B adrenergic receptor binding; angiotensin receptor binding; D1 dopamine receptor binding; enzyme binding; follicle stimulating hormone receptor binding; G-protein-coupled receptor binding; low-density lipoprotein receptor binding; mitogen-activated protein kinase binding; platelet activating factor receptor binding; protein binding; protein complex binding; protein complex scaffold; protein domain specific binding; protein kinase B binding; receptor binding; type 1 angiotensin receptor binding; type 2A serotonin receptor binding; ubiquitin protein ligase binding
Biological Process: adult walking behavior; arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; blood coagulation; brain development; detection of temperature stimulus involved in sensory perception of pain; follicle-stimulating hormone signaling pathway; G-protein coupled receptor internalization; inhibition of NF-kappaB transcription factor; negative regulation of caspase activity; negative regulation of interleukin-1 beta production; negative regulation of interleukin-12 production; negative regulation of interleukin-6 production; negative regulation of natural killer cell mediated cytotoxicity; negative regulation of protein ubiquitination; negative regulation of toll-like receptor signaling pathway; negative regulation of tumor necrosis factor production; Notch signaling pathway; platelet activation; positive regulation of calcium ion transport; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of protein ubiquitination; positive regulation of receptor internalization; positive regulation of synaptic transmission, dopaminergic; proteasomal ubiquitin-dependent protein catabolic process; protein transport; protein ubiquitination; receptor internalization; transcription from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway
Reference #:  P32121 (UniProtKB)
Alt. Names/Synonyms: ARB2; ARR2; ARRB2; arrestin 3; Arrestin beta-2; arrestin, beta 2; BARR2; Beta-arrestin-2; DKFZp686L0365
Gene Symbols: ARRB2
Molecular weight: 46,106 Da
Basal Isoelectric point: 7.59  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Hedgehog Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ARRB2

Protein Structure Not Found.


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB


Sites Implicated In
receptor internalization, induced: S14‑p, T276‑p

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S13‑p GTRVFKKssPNCKLt
1 1 S14‑p TRVFKKssPNCKLtV
1 0 K18 KKssPNCKLtVYLGK
0 1 T20‑p ssPNCKLtVYLGKRD
0 74 Y48‑p VVLVDPDyLKDRKVF
0 1 S75 DLDVLGLSFRkDLFI
0 1 K78‑ub VLGLSFRkDLFIATY
1 0 R107 RLQDRLLRKLGQHAH
1 0 K108 LQDRLLRKLGQHAHP
0 1 K153‑ac EIRAFCAkSLEEKsH
0 1 S159‑p AkSLEEKsHKRNSVR
1 0 K178 KVQFAPEKPGPQPSA
0 2 K178‑ub KVQFAPEkPGPQPSA
0 2 S197 HFLMSDRSLHLEASL
1 0 K206 HLEASLDKELYYHGE
0 1 K230‑ac NNSTKTVkkIkVSVR
0 1 K231‑ac NSTKTVkkIkVSVRQ
0 1 K233‑ac TKTVkkIkVSVRQYA
1 0 T276‑p FCKVYTItPLLSDNR
1 0 K293 RGLALDGKLkHEDTN
2 0 K295‑sm LALDGKLkHEDTNLA
1 0 K295 LALDGKLKHEDTNLA
1 1 S360 IPLPRPQSAAPETDV
3 2 T382‑p EFDTNYAtDDDIVFE
1 0 K397 DFARLRLKGMKDDDy
1 0 K400 RLRLKGMKDDDyDDQ
0 269 Y404‑p KGMKDDDyDDQLC__
  ARRB2 iso3  
S13 GTRVFKKSSPNCKLT
S14 TRVFKKSSPNCKLTV
K18 KKSSPNCKLTVYLGK
T20 SSPNCKLTVYLGKRD
Y48 VVLVDPDYLKDRKVF
S75 DLDVLGLSFRKDLFI
K78 VLGLSFRKDLFIATY
R107 RLQDRLLRKLGQHAH
K108 LQDRLLRKLGQHAHP
K153 EIRAFCAKSLEEKSH
S159 AKSLEEKSHKRNSVR
K178 KVQFAPEKPGPQPSA
K178 KVQFAPEKPGPQPSA
S197 HFLMSDRSLHLEASL
K206 HLEASLDKELYYHGE
K230 NNSTKTVKKIKVSVR
K231 NSTKTVKKIKVSVRQ
K233 TKTVKKIKVSVRQYA
T276 FCKVYTITPLLSDNR
K293 RGLALDGKLKHEDTN
K295 LALDGKLKHEDTNLA
K295 LALDGKLKHEDTNLA
S360 IPLPRPQSAPTPTPP
T394 EFDTNYATDDDIVFE
K409 DFARLRLKGMKDDDY
K412 RLRLKGMKDDDYDDQ
Y416 KGMKDDDYDDQLC__
  mouse

 
S13 GTRVFKKSSPNCkLT
S14 TRVFKKSSPNCkLTV
K18‑ub KKSSPNCkLTVYLGK
T20 SSPNCkLTVYLGKRD
Y48‑p VVLVDPDyLKDRKVF
S75‑p DLDVLGLsFRKDLFI
K78 VLGLsFRKDLFIATY
K107‑ub RLQDRLLkkLGQHAH
K108‑ub LQDRLLkkLGQHAHP
K153 EIRAFCAKSIEEKSH
S159 AKSIEEKSHKRNSVR
T178 KVQFAPETPGPQPSA
T178 KVQFAPETPGPQPSA
S198‑p FLMSDRRsLHLEASL
K207‑ub HLEASLDkELYYHGE
K231 NNSAKTVKKIRVSVR
K232 NSAKTVKKIRVSVRQ
R234 AKTVKKIRVSVRQYA
T277 FCKVYTITPLLSDNR
Q294 RGLALDGQLkHEDTN
K296 LALDGQLKHEDTNLA
K296‑ub LALDGQLkHEDTNLA
S361‑p ITLPRPQsAPRETDV
T383‑p EFDTNYAtDDDIVFE
K398 DFARLRLKGMKDDDC
K401 RLRLKGMKDDDCDDQ
C405 KGMKDDDCDDQFC__
  rat

 
S13 GTRVFKKSSPNCKLT
S14 TRVFKKSSPNCKLTV
K18 KKSSPNCKLTVYLGK
T20 SSPNCKLTVYLGKRD
Y48‑p VVLVDPDyLKDRKVF
S75 DLDVLGLSFRKDLFI
K78 VLGLSFRKDLFIATY
K107 RLQDRLLKKLGQHAH
K108 LQDRLLKKLGQHAHP
K153 EIRAFCAKSIEEKSH
S159 AKSIEEKSHKRNSVR
T178‑p KVQFAPEtPGPQPSA
T178 KVQFAPETPGPQPSA
S198 FLMSDRRSLHLEASL
K207 HLEASLDKELYYHGE
K231 NNSAKTVKKIRVSVR
K232 NSAKTVKKIRVSVRQ
R234 AKTVKKIRVSVRQYA
T277 FCKVYTITPLLSDNR
Q294 RGLALDGQLKHEDTN
K296 LALDGQLKHEDTNLA
K296 LALDGQLKHEDTNLA
S361‑p ITLPRPQsAPREIDI
T383 EFDTNYATDDDIVFE
K398 DFARLRLKGMKDDDC
K401 RLRLKGMKDDDCDDQ
C405 KGMKDDDCDDQFC__
  cow

► Hide Isoforms
 
S13 GTRVFKKSSPNCKLT
S14 TRVFKKSSPNCKLTV
K18 KKSSPNCKLTVYLGK
T20 SSPNCKLTVYLGKRD
Y48 VVLVDPDYLKDRKVF
S75 DLDVLGLSFRKDLFI
K78 VLGLSFRKDLFIANY
R107 RLQERLLRKLGQHAH
K108 LQERLLRKLGQHAHP
K153 EIRAFCAKSLEEKSH
S159 AKSLEEKSHKRNSVR
K178 KVQFAPEKPGPQPSA
K178 KVQFAPEKPGPQPSA
S197 HFLMSDRSLHLEASL
K206 HLEASLDKELYYHGE
K230 NNSTKTVKKIKVSVR
K231 NSTKTVKKIKVSVRQ
K233 TKTVKKIKVSVRQYA
T276 FCKVYTITPLLSNNR
K293 RGLALDGKLKHEDTN
K295 LALDGKLKHEDTNLA
K295 LALDGKLKHEDTNLA
S371 HPPTLLPSAVPETDA
T393 EFETNYATDDDIVFE
K408 DFARLRLKGLKDEDY
K411 RLRLKGLKDEDYDDQ
Y415 KGLKDEDYDDQFC__
  ARRB2 iso2  
S13 GTRVFKKSSPNCKLT
S14 TRVFKKSSPNCKLTV
K18 KKSSPNCKLTVYLGK
T20 SSPNCKLTVYLGKRD
Y48 VVLVDPDYLKDRKVF
S75 DLDVLGLSFRKDLFI
K78 VLGLSFRKDLFIANY
R107 RLQERLLRKLGQHAH
K108 LQERLLRKLGQHAHP
K153 EIRAFCAKSLEEKSH
S159 AKSLEEKSHKRNSVR
K178 KVQFAPEKPGPQPSA
K178 KVQFAPEKPGPQPSA
S197 HFLMSDRSLHLEASL
K206 HLEASLDKELYYHGE
K230 NNSTKTVKKIKVSVR
K231 NSTKTVKKIKVSVRQ
K233 TKTVKKIKVSVRQYA
T276 FCKVYTITPLLSNNR
K293‑sm RGLALDGkLkHEDTN
K295‑sm LALDGkLkHEDTNLA
K295 LALDGkLKHEDTNLA
S360 IALPRPQSAAPETDA
T382‑p EFETNYAtDDDIVFE
K397‑sm DFARLRLkGLkDEDY
K400‑sm RLRLkGLkDEDYDDQ
Y404 kGLkDEDYDDQFC__
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.