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Protein Page:
emerin (human)

emerin a single pass membrane protein that spans the inner nuclear membrane. A serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It interacts with lamins A and C, and mediates membrane anchorage to the cytoskeleton. Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through an exportin 1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Colocalized with BAF at the central region of the assembling nuclear rim, near spindle-attachment sites. Hyper-phosphorylated on tyrosine in cells overexpressing HER2. Directly phosphorylated by Src and Abl. Phosphorylated by Src at Y59, Y74 and Y95. May function as a downstream effector and signal integrator for tyrosine kinase signaling pathways at the nuclear envelope. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Membrane protein, integral
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: cytoplasm; endoplasmic reticulum; membrane; nuclear envelope; nuclear inner membrane; nuclear membrane; nuclear outer membrane; nucleoplasm
Molecular Function: actin binding; beta-tubulin binding; cadherin binding; protein binding
Biological Process: mitotic nuclear envelope disassembly; mitotic nuclear envelope reassembly; muscle contraction; muscle development; negative regulation of fibroblast proliferation; positive regulation of protein export from nucleus
Disease: Emery-dreifuss Muscular Dystrophy 1, X-linked
Reference #:  P50402 (UniProtKB)
Alt. Names/Synonyms: EDMD; EMD; Emerin; LEM domain containing 5; LEMD5; STA
Gene Symbols: EMD
Molecular weight: 28,994 Da
Basal Isoelectric point: 5.29  Predict pI for various phosphorylation states
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