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Protein Page:
UBE1 (human)

Overview
UBE1 an enzyme of the ubiquitin-activating E1 family. Adenylates ubiquitin at its carboxy-terminal glycine residue and thereafter links this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thiolester. There are two active sites within the E1 molecule, allowing it to accomodate two ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site. Complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: Xp11.23
Cellular Component: cytoplasm; cytosol; desmosome; endosome membrane; heterochromatin; lysosomal membrane; mitochondrion; nucleus; rough endoplasmic reticulum membrane
Molecular Function: protein binding; ubiquitin activating enzyme activity; ubiquitin-protein ligase activity
Biological Process: modification-dependent protein catabolic process; response to DNA damage stimulus
Disease: Spinal Muscular Atrophy, X-linked 2
Reference #:  P22314 (UniProtKB)
Alt. Names/Synonyms: A1S9; A1S9T; A1S9T and BN75 temperature sensitivity complementing; A1ST; AMCX1; GXP1; MGC4781; POC20; POC20 centriolar protein homolog; Protein A1S9; SMAX2; UBA1; UBA1, ubiquitin-activating enzyme E1 homolog A; UBA1A; UBE1; UBE1X; Ubiquitin-activating enzyme E1; ubiquitin-like modifier activating enzyme 1; Ubiquitin-like modifier-activating enzyme 1
Gene Symbols: UBA1
Molecular weight: 117,849 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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UBE1

Protein Structure Not Found.
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